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Recent Publications
2023
The Dictyostelium discoideum FimA protein, unlike yeast and plant fimbrins, is regulated by calcium similar to mammalian plastinsSci Rep., 13 , 16208 (2023) Optimization of the diagnosis and characterization of gibberellin-regulated protein sensitization: an Italian cohort studyAnn Allergy Asthma Immunol., S1081-1206 , 01267-X (2023) A Basic Study of the Effects of Mulberry Leaf Administration to Healthy C57BL/6 Mice on Gut Microbiota and MetabolitesMetabolites., 13 , 1003 (2023) Metabolomics of Duodenal Juice for Biliary Tract Cancer DiagnosisCancers (Basel), 15 , 4370 (2023) Enzymatic characterization of a mannuronan C5-epimerase from the subtropical brown alga Cladosiphon okamuranusFisheries Science, Antimicrobial Properties and Mode of Action of Cryptdin-4, a Mouse α-Defensin Regulated by Peptide Redox Structures and Bacterial Cultivation ConditionsAntibiotics., 12 , 1047 (2023) Application of Benchtop NMR for Metabolomics Study Using Feces of Mice with DSS-Induced ColitisMetabolites., 13 , 611 (2023) Decreased Paneth cell α-defensins promote fibrosis in a choline-deficient L-amino acid-defined high-fat diet-induced mouse model of nonalcoholic steatohepatitis via disrupting intestinal microbiotaSci Rep., 13 , 3953 (2023) Efficient recombinant production of mouse-derived cryptdin family peptides by a novel facilitation strategy for inclusion body formationMicrob Cell Fact., 22 , 9 (2023)
2022
Exploring the In situ pairing of human galectins toward synthetic O-mannosylated core M1 glycopeptides of α-dystroglycanSci Rep., 12 , 17800 (2022) Three-Dimensional Structure of the Antimicrobial Peptide Cecropin P1 in Dodecylphosphocholine Micelles and the Role of the C-Terminal ResiduesACS Omega, 7 , 31924-31934 (2022) Gibberellin-regulated proteins: Emergent allergensFront Allergy, 3 , 877553 (2022) Elucidation of the biodegradation pathways of bis(2-hydroxyethyl) terephthalate and dimethyl terephthalate under anaerobic conditions revealed by enrichment culture and microbiome analysisChem. Eng. J. 450 , 137916 (2022) Chemical analysis of amyloid β aggregation inhibitors derived from Geranium thunbergii.Bioorg Med Chem. 68 , 116840 (2022) Capsicum Allergy: Involvement of Cap a 7, a New Clinically Relevant Gibberellin-Regulated Protein Cross-Reactive With Cry j 7, the Gibberellin-Regulated Protein From Japanese Cedar Pollen.Allergy Asthma Immunol Res, 14 , 328-338 (2022) Dynamic Associations of Milk Components With the Infant Gut Microbiome and Fecal Metabolites in a Mother-Infant Model by Microbiome, NMR Metabolomic, and Time-Series Clustering Analyses.Front Nutr, 8 , 813690 (2022) Potent bactericidal activity of reduced cryptdin-4 derived from its hydrophobicity and mediated by bacterial membrane disruption.Amino Acids, 54 , 289-397 (2022)
2021
An oxidative metabolic pathway of 4-deoxy-L-erythro-5-hexoseulose uronic acid (DEHU) from alginate in an alginate-assimilating bacterium.Commun Biol, 4 , 1254 (2021) Decrease of α-defensin impairs intestinal metabolite homeostasis via dysbiosis in mouse chronic social defeat stress model.Sci Rep, 9915 , 9915 (2021) 1 H NMR metabolomic and transcriptomic analyses reveal urinary metabolites as biomarker candidates in response to protein undernutrition in adult rats.Br J Nutr, 125 , 633-643 (2021)
Gibberellin-regulated protein sensitization in Japanese cedar (Cryptomeria japonica) pollen allergic Japanese cohorts.Allergy, 76 , 2297-2302 (2021)
2020
Cordyceps militaris Fruit Body Extract Decreases Testosterone Catabolism and Testosterone-Stimulated Prostate Hypertrophy.Nutrients, 13 e50 (2020) Direct Detection of the Substrate Uptake and Release Reactions of the Light-Driven Sodium-Pump Rhodopsin.J Am Chem Soc, 142 , 16023-16030 (2020) Bactericidal effect of cationic hydrogels prepared from hydrophilic polymers.J Appl Polym Sci, 137 , e49583 (2020) Disease Progression-Associated Alterations in Fecal Metabolites in SAMP1/YitFc Mice, a Crohn's Disease Model.Metabolomics, 16 , 48 (2020) Biophysical Research in Hokkaido University, JapanBiophys Rev, 12 , 233-236 (2020) Response Surface Method for Polyhydroxybutyrate (PHB) Bioplastic Accumulation in Bacillus Drentensis BP17 Using Pineapple Peel.PLoS One, 15 , 1163-1166 (2020) Analysis of Serotonin in Human Feces Using Solid Phase Extraction and Column-Switching LC-MS/MS.Mass Spectrom (Tokyo), 15 , e0230443 (2020) Associations of Gut Microbiota, Dietary Intake, and Serum Short-Chain Fatty Acids With Fecal Short-Chain Fatty Acids.Biosci Microbiota Food Health, 39 , 11-17 (2020)
2019
Pollen/Fruit Syndrome: Clinical Relevance of the Cypress Pollen Allergenic Gibberellin-Regulated Protein.Allergy Asthma Immunol Res, 11 , 143-151 (2019) Photochemical study of a cyanobacterial chloride-ion pumping rhodopsin.Biochim Biophys Acta Bioenerg, 1860 , 136-146 (2019) The subtype of Cupressaceae pollinosis associated with Pru p 7 sensitization is characterized by a sensitization to a cross-reactive gibberellin-regulated protein in cypress pollen: BP14.Clin Exp Allergy, 49 , 1163-1166 (2019) Functional importance of the oligomer formation of the cyanobacterial H+ pump Gloeobacter rhodopsin.Sci Rep, 9 , 10711 (2019) Studies on the Quality Control of Fermented Brown Rice and Rice Bran with Aspergillus oryzae by Metabolome Analysis Using 1H-NMR.Nippon Shokuhin Kagaku Kogaku Kaishi, 66 , 139-146 (2019)
2018
A new allergen family involved in pollen food associated syndrome: snakin/gibberellin regulated proteins.J Allergy Clin Immunol, 141 , 411-414 (2018) Photochemical study of a cyanobacterial chloride-ion pumping rhodopsin.Biochim Biophys Acta Bioenerg, 1860 , 136-146 (2018) Implications for the impairment of the rapid channel closing of Proteomonas sulcata anion channelrhodopsin 1 at high Cl- concentrations.Sci Rep, 8 , 13445 (2018) Amycolatopsis oliviviridis sp. nov., a novel polylactic acid-bioplastic-degrading actinomycete isolated from paddy soil.Int J Syst Evol Microbiol, 68 , 1448-1454 (2018)
2017
R-Spondin1 expands Paneth cells and prevents dysbiosis induced by graft-versus-host disease.J Exp Med, 214 , 3507-3518 (2017) Enhanced expression of cysteine-rich antimicrobial peptide snakin-1 in Escherichia coli using an aggregation-prone protein coexpression system.Biotechnol Prog, 33 , 1520-8 (2017)
2016
Overexpression of Antimicrobial, Anticancer, and Transmembrane Peptides in Escherichia coli through a Calmodulin-Peptide Fusion System.J Am Chem Soc, 138 , 11318-26 (2016) Expression, purification and characterization of the recombinant cysteine-rich antimicrobial peptide snakin-1 in Pichia pastoris Protein Expression and Purification, , 122 , 15-22 (2016) Lipopolysaccharide-bound structure of the antimicrobial peptide cecropin P1 determined by nuclear magnetic resonance spectroscopyJournal of Peptide Science, , 22 , 214-21 (2016) Structure determination of uniformly 13 C, 15 N labeled protein using qualitative distance restraints from MAS solid-state 13 C-NMR observed paramagnetic relaxation enhancementJournal of Biomolecular NMR, ,64 , 87-101 (2016) In vivo fluorescence-correlation spectroscopy analyses of FMBP-1, a silkworm transcription factorFEBS Open Bio, , 6 , 106-25 (2016)
2015
Probing the Cl- -pumping photocycle of pharaonis halorhodopsin: Examinations with bacterioruberin, an intrinsic dye,
and membrane potential-induced modulation of the photocycleBiochim. Biophys. Acta, , 1847 , 748-58 (2015) Efficient production of a correctly folded mouse a-defensin, cryptdin-4, by refolding during inclusion body solubilizationProtein Expression and Purification, 112 , 21-28 (2015). 抗菌ペプチド利用の最前線～特集にあたってバイオインダストリー , 32 , 3 (2015)
抗菌ペプチドをプローブとして利用した微生物検出法の開発バイオインダストリー , 32, 42-48 (2015)
2014
Interaction between tachyplesin I, an antimicrobial peptide derived from horseshoe crab, and lipopolysaccharideBiochim. Biophys. Acta - Proteins and Proteomics, 1844 , 527-534 (2014).
2013
Role of S-palmitoylation on IFITM5 for the interaction with FKBP11 in osteoblast cellsPLoS One, 8 , e75831 (2013). Overexpression of an antimicrobial peptide derived from C. elegans using an aggregation-prone protein coexpression systemAMB Express, 3 , 45 (2013). A new approach to detect small peptides clearly and sensitively by Western blotting using a vacuum-assisted detection methodBiophysics, 9 , 79-83 (2013). Development of a novel multiplex lateral flow assay using an antimicrobial peptide for the detection of Shiga toxin-producing Escherichia coli.J. Microbiol. Methods., 93 , 251-256 (2013).
Molecular mechanisms of the cytotoxicity of human alpha-lactalbumin made lethal to tumor cells (HAMLET) and other protein-oleic acid complexesJ. Biol. Chem., 288 , 14408-14416, 2013. 共発現による封入体化発現法を用いた組換えペプチド生産バイオインダストリー , 30 , 35-40 (2013)
2012
Bone formation by porous chitosan / hydroxyapatite composite with rhBMP-2 on rat calvariaHokkaido J. Dent. Sci., 32 , 166-176 (2012). Structural characterization of a trapped folding intermediate of pyrrolidone carboxyl peptidase from a hyperthermophileBiochemistry, 51 , 6089-6096 (2012). Homo-trimer Formation and Dissociation of pharaonis Halorhodopsin in Detergent SystemBiophys. J., 102 , 2906-2915 (2012). 鱗翅目昆虫で働く生体防御タンパク質の構造生物学蚕糸・昆虫バイオテック , 81 , 115-123 (2012)
2011
Expression of salinarum halorhodopsin in Escherichia coli cells: solubilization in the presence of retinal yields the natural stateBiochim. Biophys. Acta, 1808 , 2905-2912, (2011). The structure of Physarum polycephalum hemagglutinin I suggests a minimal carbohydrate recognition domain of legume lectin foldJ. Mol. Biol., 405 , 560-569 (2011).
2010
Development of an injectable chitosan/marine collagen composite gelBiomedical Materials, 5 065009 (2010). STPR, A 23-amino-acid tandem repeat domain, found in the human function-unknown protein ZNF821Biochemistry, 49 , 8367-8375 (2010). Polyglutamine tract-binding protein-1 binds to U5-15kD via a continuous 23-residue segment of the C-terminal domain.Biochim. Biophys. Acta - Proteins and Proteomics, 1804 , 1500-1507 (2010).
Structure-activity relationship of a novel pentapeptide with cancer cell growth-inhibitory activity.J.Peptide Sci., 16 , 242-248 (2010).
2009
C-terminal elongation of growth-blocking peptide enhances its biological activity and micelle binding affinityJ. Biol. Chem., 284 , 29625-29634 (2009). A novel -defensin structure: big defensin changes its N-terminal structure to associate with the target membraneBiochemistry, 48 , 7629-7635 (2009). A Novel Peptide Mediates Aggregation and Migration of Hemocytes From an InsectCurrent Biology, 19 , 779-785 (2009). DNA-Binding Property of the Novel DNA-Binding Domain STPR in FMBP-1 of the Silkworm Bombyx mori Journal of Biochemistry, , 146 , 103-11 (2009). Polyglutamine tract binding protein-1 is an intrinsically unstructured proteinBiochim. Biophys. Acta - Proteins and Proteomics, 1794 , 936-943 (2009). X-ray crystallography and structural stability of digestive lysozyme from cow stomachFEBS J., 276 , 2192-2200 (2009). Role of Arg123 in light-driven anion pump mechanisms of pharaonis halorhodopsinPhotochem. Photobiol., 85 , 547-555 (2009). Halorhodopsin from Natronomonas pharaonis forms a trimer even in the presence of a detergent,
dodecyl-beta-D-maltosidePhotochem. Photobiol., 85 , 130-136 (2009).
2008
Heat-treatment method for producing fatty acid-bound alpha-lactalbumin that induces tumor cell deathBiochem.Biophys.Res.Commun., 376 , 211-214 (2008). A Novel beta-defensin Structure: a Strategy of Big Defensin for a Resistance by Gram-positive BacteriaBiochemistry, 47 , 10611-10619 (2008). Structural Properties of the DNA-Bound Form of a Novel Tandem Repeat DNA-Binding Domain, STPRProteins, 72 , 414-426 (2008). Spontaneous asparaginyl deamidation of canine milk lysozyme under mild conditionsProteins, 72 , 313-322 (2008). Unfolding and aggregation of transthyretin by the truncation of 50 N-terminal amino acids.Proteins, 72 , 261-269 (2008).
2007
The Structure of a Novel Insect Peptide Explains Its Ca(2+) Channel Blocking and Antifungal Activities Biochemistry, 46 , 46 , 13733 - 41 (2007). Equilibrium and Kinetics of the Folding and Unfolding of Canine Milk Lysozyme Biochemistry, 46 , 5238 - 5251 (2007). The solution structure of horseshoe crab antimicrobial peptide tachystatin B with an inhibitory cystine-knot motifJ. Pept. Sci., 13 , 269-279 (2007). Structural Approach to a Novel Tandem Repeat DNA-Binding Domain, STPR, by CD and NMR Biochemistry, 46 , 1703-1713 (2007). Destabilization of Transthyretin by Pathogenic Mutations in the DE loopPROTEINS: Structure, Function, and Bioinformatics, 66 , 716-725 (2007).
2006
N-Terminal Mutational Analysis of the Interaction between Growth-Blocking Peptide (GBP) and Receptor of Insect Immune CellsProtein & Peptide Lett., 13 , 815-822 (2006). Differential Scanning Calorimetry of a Metalloprotein under Controlled Metal-Ion ActivityProtein J., 25 , 475-482 (2006). A Novel N14Y Mutation in Connexin26 in KID Syndrome ? Analyses of Altered Gap Junctional Communication and Molecular Structure of N-Terminus of Mutated Connexin26Am. J. Pathology, 169 , 416-423 (2006). Preparation and Observation of Fresh-frozen Sections of the Green Fluorescent Protein Transgenic Mouse HeadActa Histochemica et Cytochemica, 39 , 31-34 (2006).
2005
Disassembling and bleaching of chloride-free pharaonis halorhodopsin by octyl-beta-glucosideBiochemistry, 44 , 12923-12931 (2005). Effects of the Stabilization of the Molten Globule State on the Folding Mechanism of ƒ¿-Lactalbumin: A Study of a Chimera of Bovine and Human ƒ¿-LactalbuminProteins, 61 , 356-365 (2005). Role of Putative Anion-Binding Sites in Cytoplasmic and Extracellular Channels of Natronomonas pharaonis HalorhodopsinBiochemistry, 44 , 4775-4784 (2005) Interaction of dopamine and acetylcholine with an amphiphilic resorcinarene receptor in aqueous micelle systemBioorganic & Medicinal Chemistry Letters, 15 , 1367-1370 (2005)
2004
The Gly-Gly Linker Region of the Insect Cytokine Growth Blocking Peptide (GBP) is Essential for ActivityJ. Biol. Chem., 279 , 51331-51337 (2004). Effect of Hydrostatic Pressure on Conformational Changes of Canine Milk Lysozyme between the Native, Molten Globule, and Unfolded StatesBiochim. Biophys. Acta, 1702 , 129-136 (2004). A Non-Native alpha-Helix Is Formed in the beta-Sheet Region of the Molten Globule State of Canine Milk LysozymeProtein J., 23 , 335-342 (2004). Volumetric behavior of the molten globule state of canine milk lysozymeProtein Pept Lett., 11 , 325-330 (2004).
2003
Solution structure of epiregulin and the effect of its C-terminal domain for receptor binding affinityFEBS Lett., 553 , 232-238 (2003). Roles of aromatic residues in the structure and biological activity of the small cytokine, growth-blocking peptide (GBP)J. Biol. Chem., 278 , 10778-83 (2003). Structure Determination and Conformational Change Induced by Tyrosine Phosphorylation of the N-terminal Domain of the alpha-Chain of Pig Gastric H+ /K+ -ATPaseBiochem. Biophys. Res. Commun., 300 , 223-229 (2003).
2002
Production and Characterization of Recombinant Tachycitin, the Chitin-Binding ProteinProtein Engineering, 15 , 763-769(2002). Structure and activity of insect cytokine GBP which stimulates the EGF receptorMol. Cells, 14 , 1-8 (2002). Solution structure of betacellulin, a new member of EGF-family ligandsBiochem. Biophys. Res. Commun., 294 , 1040-1046 (2002). Structural Analysis of an Insect Lysozyme Exhibiting Catalytic Efficiency at Low TemperaturesBiochemistry, 41 , 12086 - 12092 (2002). Expression and purification of small cytokine growth-blocking peptide (GBP) from armyworm Pseudaletia separata by the optimized fermentation metnod using methylotrophic yeast Pichia pastoris Protein Expression and Purification, 25 , 416-425 (2002). ABF-1 and ABF-2, ASABF-type antimicrobial peptide genes in Caenorhabditis elegans. Biochem J., 361 , 221-230 (2002).
2001
Construction of an expression system of insect lysozyme lacking thermal stability: the effect of selection of signal sequence on level of expression in the Pichia pastoris expression system.Protein Eng., 14 , 705-710 (2001). Thermal Stability and Enzymatic Activity of a Smaller Lysozyme from Silk Moth (Bombyx mori )J. Protein Chem., 20 , 107-113 (2001). Structure and activity of the insect cytokine growth-blocking peptide. Essential regions for mitogenic and hemocyte-stimulating activities are separate.J. Biol. Chem., 276 , 31813-31818 (2001).
2000
In vitro antimicrobial properties of recombinant ASABF, an antimicrobial peptide isolated from the nematode ascaris suumAntimicrob. Agents Chemother., 44 , 2701-2705 (2000).
1999
Solution Structure of an Insect Growth Factor, Growth-binding PeptidesJ. Biol. Chem., 274 , 1887-1890 (1999)
1998
