Molecular mechanisms of gene regulation

Gene regulation is essential for all organisms to adapt to changing environments. Cellular differentiation also requires gene regulation. In many cases, these adaptive responses are mediated by transcriptional regulators that control the expression levels of functional proteins. The interest of our group is to understand molecular mechanisms of gene regulation, focusing on structural and functional analyses of transcriptional regulators by combining X-ray crystallography and other biochemical methods such as SELEX analysis.

Transcriptional factors whose structures were determined in our group

Transcriptional factors whose structures were determined in our group (PDB code)

  • From Pyrococcus horikoshii
    PH1061 (1UB9), PH1161 (1UDD), PH1932 (1ULY)
  • From Corynebacterium glutamicum
    CGL2612 (1V7B, 2DH0, 2YVE, 2YVH), CGL2915 (2DI3), CGL2947 (2DU9, 2EK5)
  • From Streptomyces coelicolor
    SCO0332 (2ZB9), SCO0337 (2DG7), SCO4008 (2D6Y), SCO5550 (2DG6), SCO7518 (2DG8), SCO7815 (2ZCX)