北海道大学 西村研究室 Nishimura Lab, Hokkaido University


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本文へジャンプ


Publications


 

coming soon....

 387 Murakami K, Kambe D, Yokoi Y, Wakui H, Hayakawa S, Hirane N, Koide R, Otaki M, Nagahori N, and Nishimura S-I., “Smart Nanomedicine Targeting Endocytosis Mediated by Cancer Cell Surface Neuraminidase-1”, Adv. NanoBiomed Res 3, 2300076 (2023)
 386 Wakui H., Yokoi Y., Horidome C., Ose T., Yao M., Tanaka Y., Hinou H., Nishimura S-I., “Structural and molecular insight into antibody recognition of dynamic neoepitope in membrane tethered MUC1 of pancreatic cancer cells and secreted exosomes”, RSC Chem. Biol. 4, 564-572 (2023)
 385 Villones Lareno L, Ludwig A-K., Kumeta H., Kikuchi S., Ochi R., Nishimura S-I., Hans-Joachim Gabius, Herbert Kaltner, Hinou H., “Altering the Modular Architecture of Galectins Affects its Binding with Synthetic a-Dystroglycan O-Mannosylated Core M1 Glycoconjugates In situ”, ChemBioChem. in press  doi: 10.1002/cbic.202200783
 384 Villones Lareno L., Ludwig A-K., Kumeta H., Kikuchi S., Ochi R., Aizawa T., Nishimura S-I., Gabius H.-J., Hinou H., “Exploring the In situ Pairing of Human Galectins toward Synthetic O-Mannosylated Core M1 Glycopeptides of α-Dystroglycan”, Sci. Rep. 17800 (2022)  doi: 10.1038/s41598-022-22758-0
 383 Otaki M., Hirane N., Natsume-Kitatani Y., Nogami Itoh M., Shindo M., Kurebayashi Y., Nishimura S-I., “Mouse tissue glycome atlas 2022 highlights inter-organ variation in major N-glycan profiles”, Sci. Rep. 17804 (2022)  doi: 10.1038/s41598-022-21758-4
 382
Matsushita T., Hinou H., Nishimura S-I., “Generation 6 polyamidoamine dendrimer provides an ideal nanoparticular platform for enzyme-assisted synthesis of glycopeptides having bulky and complex glycans”, Chem. Lett. 51, 1044-1048 (2022)
 381 Shiratori K., Yokoi Y., Wakui H., Hirane N., Otaki M., Hinou H., Yoneyama T., Hatakeyama T., Kimura S., Ohyama C., Nishimura Shin-Ichiro, “Selective reaction monitoring approach using structure-defined synthetic glycopeptides for validating glycopeptide biomarkers pre-determined by bottom-up glycoproteomics”, RSC Adv. 12, 21385-21393 (2022)
380 Takei D., Harada K., Nouso K., Miyahara K., Dohi C., Matsushita H., Kinugasa H., Hiraoka S., Nishimura S-I and Okada H., “Clinical utility of a serum glycome analysis in patients with colorectal cancer”, J. Gastroenterol. Hepatol. 37, 727-733 (2022)
 379 Koide R., Hirane N., Kambe D., Yokoi Y., Otaki M., Nishimura S-I., “Antiadhesive nanosome elicits role of glycocalyx of tumor cell-derived exosomes in the organotropic cancer metastasis”, Biomaterials 280, 121314 (2022) 
 378 Takahashi H., Kamiyama T., Hirane N., Kobayashi N., Aiyama T., Nagatsu A., Shimada S., Orimo T., Kakisaka T., Fukai M., Yokoo H., Kamachi H., Nishimura S-I., Taketomi A., “Analysis of the correlation between alterations in N‑glycans and invasiveness in liver cancer cell lines”, Oncol. Rep. 44, 2757-2769 (2020) 
 377 Pablo A. Guillen-Poza., Elena Matilde Sánchez-Fernández., Gerard Artigas., José Manuel García Fernández., Hinou H., Carmen Ortiz Mellet, Nishimura S-I., Fayna Garcia-Martin., “Amplified detection of breast cancer autoantibodies using MUC1-based Tn antigen mimics”, J. Med. Chem. 63, 8524-8533 (2020)
 376

Yokoi Y., Nishimura S-I., “Effect of Site‐specific O-Glycosylation on the Structural Behavior of NOTCH1 Receptor Extracellular EGF‐like Domains 11 and 10”, Chem. Eur. J.  26, 12363-12372 (2020)

 375 Wakui H., Tanaka Y., Ose T., Matsumoto I., Kato K., Yao M., Tachibana T., Sato M., Naruchi K., Garcia-Martin F., Hinou H., Nishimura S-I., A Straightforward Approach to Antibodies Recognising Cancer Specific Glycopeptidic Neoepitopes”, Chem. Sci. 11, 4999-5006 (2020)
 374 Iris A. Bermejo., Claudio D. Navo., Jorge Castro-López., Ana Guerreiro., Ester Jiménez-Moreno., Elena M. Sánchez Fernández., Fayna García-Martín., Hinou H., Nishimura S-I., José M. García Fernández., Carmen Ortiz Mellet., Alberto Avenoza.,  Jesús H.Busto., Gonçalo J. L. Bernardes., Ramón Hurtado-Guerrero., Jesús M. Peregrina and Francisco Corzana, “Synthesis, Conformational Analysis and in vivo Assays of an Anti-cancer Vaccine that features an Unnatural Antigen based on a sp2-Iminosugar Fragment”, Chem. Sci. 11, 3996-4006 (2020)
 373

Hayakawa S., Matsushita T., Yokoi Y., Wakui H., Garcia-Martin F., Hinou H., Matsuoka K., Nouso K., Kamiyama T., Taketomi A and Nishimura S-I., Impaired OGlycosylation at Consecutive Threonine TTX Motifs in Mucins Generates Conformationally Restricted Cancer Neoepitopes”, Biochemistry 59, 1221-1241 (2020)

 372 Soma O., Hatakeyama S., Yoneyama T., Saito M., Sasaki H., Tobisawa Y., Noro D., Suzuki Y., Tanaka M., Nishimura S-I., Harada H., Ishida H., Tanabe K., Satoh S., Ohyama C., "Serum N‑glycan profiling can predict biopsy‑proven graft rejection after living kidney transplantation", Clin. exp. nephrol . 24, 174-184 (2020)
371
Matsumoto T., Yoneyama T., Tobisawa Y., Ishibashi Y., Yamamoto H., Yoneyama T., Hashimoto Y., Ito H., Nishimura S-I and Ohyama C., “Serum N-glycan profiling is a potential biomarker for castration-resistant prostate cancer”, Sci. Rep. 9, 168761 (2019)
370 Koide R and Nishimura S-I., Antiadhesive nanosomes facilitate targeting of lysosomal GlcNAc salvage pathway through derailed cancer endocytosis ”, Angew. Chem. Int. Ed. 58, 14513-14518 (2019)
 369 Hideshima S., Hayashi H., Hinou H., Nambuya S., Kuroiwa S., Nakanishi T., Momma T., Nishimura S-I., Sakoda Y., Osaka T., “Glycan-immobilized dual-channel field effect transistor biosensor for the rapid identification of pandemic influenza viral particles”, Sci. Rep. 9, 11616 (2019)
368 Hinou H., Kikuchi S., Ochi R., Igarashi K., Takada W and Nishimura S-I., “Synthetic glycopeptides reveal specific binding pattern and conformational change at O-mannosylated position of α-dystroglycan by POMGnT1 catalyzed GlcNAc modification”, Bioorgan. Med. Chem. 27, 2822-2831 (2019)
 367 Gebrehiwot Abrha G., Seifu Melka D., Mamo Kassaye Y., Gemechu T., Lako W., Hinou H and Nishimura S-I., “Exploring serum and Immunoglobulin G N-glycome as diagnostic biomarkers for early detection of breast cancer in Ethiopian women”, BMC Cancer. 19, 588 (2019)
 366 Flechner A., Butschak G., Löffler A., Rühmann J., Nishimura S-I., Dölling R., Purfürst B.,  Goletz S., Danielczyk A., Karsten U., “Cluster binding studies with two anti-Thomsen-Friedenreich (anti-core-1, CD176) antibodies: evidence for a quadruple epitope”, Int. Immunopharmacol. 72, 186-194 (2019)
 365 Sanes T. Jurgen., Hinou H., Lee YC and Nishimura S-I., “Glycoblotting of Egg White Reveals Diverse N-glycan Expression in Quail Species”, J. Agr. Food Chem. 67, 531-540 (2019) 
 364 Gebrehiwot Abrha G., Seifu Melka D.,  Mamo Kassaye Y., Rehan F.I., Rangappa S., Hinou H., Kamiyama T and Nishimura S-I., “Healthy human serum N-glycan profiling reveals the influence of ethnic variation on the identified cancer-relevant glycan biomarkers, PLOS ONE  13, e0209515 (2018)
 363 Ishihara S., Aoki K., Mizutani T., Amano M., Nishimura S-I and Haga H., “Glycosphingolipid GM2 induces invasiveness in irradiation-tolerant lung cancer cells”, Cell Struct. Funct. 43, 177-185 (2018)
 362 Hammura K., Ishikawa A., Ravi H.V., Miyoshi R., Yokoi Y., Tanaka M., Hinou H and Nishimura S-I., “Synthetic glycopeptides allow for the quantitation of scarce non-fucosylated IgG Fc N-glycans of therapeutic antibody”, ACS Med. Chem. Lett. 9, 889-894 (2018) 
 361 Yogesh K.V., Kamiyama T., Ohyama C.,  Yoneyama T., Nouso K., Kimura S., Hinou H and Nishimura S-I., “Synthetic glycopeptides as a designated standard in focused glycoproteomics to discover serum cancer biomarkers”, MedChemComm 9, 1351-1358 (2018)
 360 Lukas Heger., Silke Balk., Jennifer J. Lühr., Gordon F. Heidkamp., Christian H. Lehmann., Ariawan Purbojo., Arndt Hartmann., Fayna Garcia-Martin., Shin-Ichiro Nishimura., Robert Cesnjevar., Falk Nimmerjahn, and Diana Dudziak., “CLEC10A is a specific marker for human CD1c+ DCs and enhances their Toll-like receptor 7/8 induced cytokine secretionr”, Front. Immunol. 9, 744 (2018)
 359 Tanaka T., Yoneyama T., Noro D., Imanishi K., Kojima Y., Hatakeyama S., Tobisawa Y.,  Mori K., Yamamoto H., Imai A., Yoneyama T.,  Hashimoto Y., Koie T., Tanaka M., Nishimura S-I., Kurauchi S., Takahashi I and Ohyama C., “Aberrant N-Glycosylation Profile of Serum Immunoglobulins is a Diagnostic Biomarker of Urothelial Carcinomas, Int. J. Mol. Sci. doi:10.3390/ijms18122632
 358 Somovilla V.J., Bermeijo I.A., Albuquerque I.S., Martínez-S. N., Castro-Lopez J., Garcia-Martin F., Companon I.., Hinou H., Nishimura S-I., Jimenez-Barbero J., Asensio J.L, Avenoza G., Busto J.H., Hurtado-Guerrero. R., Peregrina J.M., Bernardes G.J.L and Corzana F., “The use of fluoroproline in MUC1 antigen enables efficient detection of antibodies in patients with prostate cancer”, J. Am. Chem. Soc. 129, 18255-18261 (2017)
 357 Artigas G., Monteiro J.T., Hinou H.,  Nishimura S-I., Lepenies B and Garcia-Martin F., “Glycopeptides as Targets for Dendritic Cells: Exploring MUC1 Glycopeptides Binding Profile toward Macrophage Galactose-Type Lectin (MGL) Orthologs”, J.Med.Chem. 60, 9012-9021 (2017)
 356 Naito S., Takahashi T., Onoda J., Uemura S.,  Ohyabu N., Takemoto H., Yamane S., Fujii I., Nishimura S-I and Numata Y., “Generation of Novel Anti-MUC1 Monoclonal Antibodies with Designed Carbohydrate Specificities Using MUC1 Glycopeptide Library”, ACS Omega 2, 7493-7505 (2017)
 355 Noro D., Yoneyama T., Hatakeyama S., Tobisawa Y., Mori K., Hashimoto Y., Koie T.,  Tanaka M., Nishimura S-I., Sasaki H., Saito M., Harada H., Chikaraishi T., Ishida H., Tanabe K., Satoh S and Ohyama C., “Serum Aberrant N-Glycan Profile as a Marker Associated with Early Antibody-Mediated Rejection in Patients Receiving a Living Donor Kidney Transplant”, Int. J. Mol. Sci.  18, 1731 (2017)
 354 Furukawa T., Hinou H., Takeda S., Chiba H., Nishimura S-I and Shu-Ping Hui., “An efficient glycoblotting-based analysis of oxidized lipids in liposomes and a lipoprotein”, ChemBioChem. 18, 1903-1909 (2017)
 353 Hayakawa S., Yokoi Y., Hinou H and Nishimura S-I., “Chemical synthesis demonstrates dynamic O-glycosylation regulates folding and functional conformation of a pivotal EGF12 domain of human NOTCH1 receptor”, Biochemistry. 56, 4379-4391 (2017) 
352 Nagaraja Brijesha., Nishimura S-I and Sosalegowda Aparna., “Comparative Glycomics of Fat Globule Membrane Glycoconjugates from Buffalo (Bubalus bubalis) Milk & Colostrum”, J. Agr. Food chem. 65, 1496-1506 (2017)
 351 Artigas G., Hinou H., Garcia-Martin F., Hans-Joachim Gabius and Nishimura S-I., “Synthetic Mucin-like Glycopeptides as Versatile Tools to Measure Effects of Glycan Structure/Density/Position on Interaction with Adhesion/Growth-regulatory Galectins in Arrays”, Chem. Asian J. 12, 159-167 (2017) 
350 Ohyabu N., Kakiya K., Yokoi Y., Hinou H and Nishimura S-I., “Convergent solid-phase synthesis of macromolecular MUC1 models truly mimicking serum glycoprotein biomarkers of interstitial lung diseases”, J. Am. Chem. Soc. 138, 8392-8395 (2016)
349 Roger S. Tan., Hinou H., and Nishimura S-I., “Novel β-galactosynthase - β-mannosynthase dual activity of β-galactosidase from Aspergillus oryzae uncovered using monomer sugar substrates”, RSC Adv. 6, 50833-50836 (2016)
348 Kaneko K., Takamatsu T., Inomata T., Oikawa K., Itoh K., Hirose K., Amano M., Nishimura  S-I., Toyooka K., Matsuoka K., Pozueta-Romero and Javier, Mitsui T., “N-glycomic and microscopic subcellular localization analyses of NPP1, 2 and 6 strongly indicate that trans-Golgi compartments participate in the Golgi-to-plastid traffic of nucleotide pyrophosphatase/phosphodiesterases in rice”, Plant Cell Physiol57, 1610-1628 (2016)
347 Mamatha Bhanu L.S., Nishimura S-I., and Aparna H.S., “Inhibitory potential of Buffalo (Bubalus bubalis) colostrum immunoglobulin G on Klebsiella pneumoniae”, Int. J. Boil. Macromol. 88, 138-145 (2016)
346 Rangappa S., Gerard Artigas., Miyoshi M., Yokoi Y., Hayakawa S., Fayna Garcia-Martin.,  Hinou H., and Nishimura S-I., “Effects of the multiple O-glycosylation states on antibody recognition of the immunodominant motif in MUC1 extracellular tandem repeats”, MedChemComm 7, 1102-1122 (2016)
345

Sato R., Tsuchiya K., Matsuzaki H., Takei N., Itoh H., Kanayama N., Suda T., Watanabe H., Ohashi T., Tanaka M., Nishimura S-I and Maekawa M., “Fetal environment and glycosylation status in neonatal cord blood: a comprehensive mass spectrometry-based glycosylation analysis”, Medicine 94, e3219 (2016)

344 Gizaw S., Ohashi T., Tanaka M., Hinou H and Nishimura S-I., “Glycoblotting method allows for rapid and efficient glycome profiling of human Alzheimer’s disease brain, serum and cerebrospinal fluid towards potential biomarker discovery”, BBA-GenSubjects 1860, 1716-1727 (2016)
343 Hayakawa S., Koide R., Hinou H., and Nishimura S-I., “Synthetic Human NOTCH1 EGF Modules Unraveled Molecular Mechanisms for the Structural and Functional Roles of Calcium Ions and O-glycans in the Ligand-binding Region”, Biochemistry 55, 776-787 (2016)
342 Hinou H., Abe Y., Hayakawa H., Naruchi K., Fjitani N and Nishimura S-I.,
Solid-phase Synthesis of C-mannosylated Glycopeptide on WSXWS Motif of Human Erythropoietin Receptor”, Tetrahedron let57, 791-795 (2016)
341

Inafuku S., Noda K., Amano M., Nishimura S-I and Ishida S., “Increase of Sialylated N-glycans in Eyes with Neovascular Glaucoma Secondary to Proliferative Diabetic Retinopathy”, Curr. Eye Res. 41, 721-724 (2016)

340 Tomoda T., Nouso K., Kato H., Miyahara K., Dohi C., Morimoto Y., Kinugasa H., Akimoto Y., Matsumoto K., Yamamoto N., Noma Y., Horiguchi S., Tsutsumi K., Amano M., Nishimura S-I and Yamamoto K., Alteration of serum N-glycan profile in patients with autoimmune pancreatitis”, Pancreatology 16, 44-51 (2016)
339

Kitatsuji C., Izumi K., Nambu S., Kurogochi M., Uchida T., Nishimura S-I., Iwai K., Mark R. O’Brian, Ikeda-Saito M and Ishimori K., “Protein oxidation mediated by heme-induced active site conversion specific for heme-regulated transcription factor, iron response regulator”, Sci. Rep. 6, 18703 (2016)

 338

Udono M., Fujii K., Harada G., Tsuzuki Y., Kadooka K., Zhang P., Fujii H., Amano M.,  Nishimura S-I., Tashiro K., Kuhara S and Katakura Y., “Impaired ATP6V0A2 expression contributes to Golgi dispersion and glycosylation changes in senescent cells, Sci. Rep. 5, 17342 (2015)

 337

Akimoto Y., Nouso K., Kato H., Miyahara K.,  Dohi C., Morimoto Y., Kinugasa H., Tomoda T., Yamamoto N., Tsutsumi K., Kuwaki K., Onishi H., Ikeda F., Nakamura S., Shiraha H.,  Takaki A., Okada H., Amano M., Nishimura S-I and Yamamoto K. “Serum N-glycan profiles in patients with intraductal papillary mucinous neoplasms of the pancreas”, Pancreatology 15, 432-438 (2015)

 336 Rehan I., Ueda K., Mitani T., Amano M., Hinou H, Ohashi T., Kondo S and Nishimura S-I., “Large-scale Glycomics of Livestock: Discovery of Highly Sensitive Serum Biomarkers Indicating an Environmental Stress Affecting Immune Responses and Productivity of Holstein Dairy Cows”, J. Agric. Food. Chem. 63, 10578-10590 (2015)
335 Helena Coelho., Takahiko Matsushita., Gerard Artigas., Hiroshi Hinou., F. Javier Canada., Richard Lo-Man., Claude Leclerc., Eurico J. Cabrita., Jesus Jimenez-Barbero., Shin-Ichiro Nishimura., Fayna Garcia-Martin and Filipa Marcelo., The Quest for Anticancer Vaccines: Deciphering the Fine-Epitope Specificity of Cancer-Related Monoclonal Antibodies by Combining Microarray Screening and Saturation Transfer Difference NMR, J.Am.Chem.Soc. 137, 12438-12441 (2015)
334 Mamatha Bhanu L.S., Amano M., Nishimura S-I and Aparna H.S., “Glycome characterization of immunoglobulin G from buffalo (Bubalus bubalis ) colostrum”, Glycoconj. J 32, 625-634 (2015)
333 Roger S. Tan., Naruchi K., Amano M., Hinou H and Nishimura S-I., “Rapid Endolysosomal Escape and Controlled Intracellular Trafficking of Cell Surface Mimetic Quantum-Dots-Anchored Peptides and Glycopeptides”, ACS Chem. Biol. 10, 2073-2086 (2015)
332 Inafuku S., Noda K., Amano M., Murata M., Saito W., Ohashi T., Kanda A., Nishimura S-I and Ishida S., “Alteration of N-glycan profiles in Diabetic Retinopathy”, Invest. Ophthalmol. Vis. Sci. 56, 5316-5322 (2015)
331 Gizaw S., Koda T., Amano M., Kamimura K., Ohashi T., Hinou H and Nishimura S-I., “A comprehensive glycome profiling of Huntington's disease transgenic mice”,  BBA-GenSubjects 1850, 1704-1718 (2015)
 330 Miyahara K., Nouso K., Morimoto Y., Kinugasa H., Kato H., Yamamoto N., Tsutsumi K.,  Kuwaki., K., Onishi H., Ikeda F., Nakamura S., Shiraha H., Takaki A., Nakahara T., Miura Y., Asada H., Amano M., Nishimura S-I and Yamamoto K., “Prognostic Value of Altered N-Glycosylation of Circulating Glycoproteins in Patients With Unresectable Pancreatic Cancer Treated With Gemcitabine”, Pancreas 44, 551-556 (2015) 1536-4828
329 Miyahara K., Nouso K., Dohi C., Morimoto Y., Kinugasa H., WADA N., Takeuchi Y., Kuwaki K.,  Ohnishi H., Ikeda F., Miyake Y., Nakamura S.,  Shiraha H., Takaki A., Amano M., Nishimura S-I and Yamamoto K., “Alteration of N-glycan profiles in patients with chronic hepatitis and hepatocellular carcinoma”, Hepatol. Res. 45, 986-993 (2015)
328 Yamasaki Y., Nouso K., Miyahara K., Wada N., Dohi C., Morimoto Y., Takeuchi Y.,  Yasunaka T., Kuwaki K., Onishi H., Ikeda F., Miyake Y., Nakamura S., Shiraha H., Takaki A., Amano M., Nishimura S-I and Yamamoto K., “Use of noninvasive serum glycan markers to distinguish nonalcoholic steatohepatitis from simple steatosis”, J. Gastroen. Hepatol. 30, 528-534 (2015)
327 Kimura K., Nishimura S-I., Miyoshi R., Hoque A., Miyoshi T and Watanabe Y., “Application of glyco-blotting for identification of structures of polysaccharides causing membrane fouling in a pilot-scale membrane bioreactor treating municipal wastewater”, Bioresource Technol. 179, 180-186 (2015)
326 Watanabe N., Hara Y., Kono A., Ohashi T., Amano M and Nishimura S-I., “Nutriglycomics in Mice Fed High-Fat or Low-Protein Diets”, Journal of Nutrition & Metabolism 1(2), 4-8 (2014)
325 Terashima M., Amano M., Onodera T., Nishimura S-I and Iwasaki N., “Quantitative glycomics monitoring of induced pluripotent and embryonic stem cells during neuronal differentiation”, Stem. Cell Res., 13, 454-464 (2014)
 324 Filipa Marcelo., Fayna Garcia-Martin., Takahiko Matsuhsita., Joao Sardinha., Helena Coelho., Anneloes Qude-Vrielink., Christiane Koller., Sabine Andre., Eurico J. Cabrita., Hans-Joachim Gabius., Shin-Ichiro Nishimura., Jesus Jimenez-Barbero and F. Javier Canada., “Delineating binding modes of Gal/GalNAc and structural elements of the molecular recognition of tumor-associated mucin glycopeptides by the human macrophage galactose-type lectin”, Chem. Euro. J. 20, 16147-16155 (2014)
323 Garcia-Martin F., Matsushita T., Hinou H and Nishimura S-I., “Fast epitope mapping for the anti-MUC1 monoclonal antibody by combining one-bead-one-glycopeptide library and microarray platform”, Chem. Eur. J., 20, 15891-15902 (2014)

322

Ishibashi Y., Tobisawa Y., Hatakeyama S., Ohashi T., Tanaka M., Narita S., Koike T., Habuchi T., Nishimura S-I., Ohyama C and Yoneyama T.,“Serum tri- and tetra-antennary N-glycan is a potential predictive biomarker for castration-resistant prostate cancer”, The prostate 74, 1521-1529 (2014)

321

Inafuku S., Noda K., Amano M., Ohashi T., Yoshizawa C., Saito W., Kanda A., Nishimura S-I and Ishida S.,  “A comparison of N-glycan profiles in human plasma and vitreous fluid”, Graefes Arch. Clin. Exp. Ophthalmol, 252,1235-1243 (2014)

320

Ishida J., Hinou H., Naruchi K and Nishimura S-I., “Synthesis of neoglycosphingolipid from nethoxyamino-functionalized ceramide”, Bioorg. Med. Chem. Lett. 24, 1197-1200 (2014)

319

Hatakeyama S., Amano M., Tobisawa Y., Yoneyama T., Tsuchiya N., Habuchi T., Nishimura S-I and Ohyama C., “Serum N-glycan alteration associated with renal cell carcinoma detected by high-throughput glycan analysis”, J. Urol. 191, 805-813 (2014)

318

Matsushita T., Takada W., Igarashi K., Naruchi K., Miyoshi R., Garcia-Martin F.,  Amano M., Hinou H and Nishimura S-I., “A straightforward protocol for the preparation of high performance microarray displaying synthetic MUC1 glycopeptides”, BBA-GenSubjects 1840, 1105-1116 (2014)

317

Ishihara T., Kakiya K., Takahashi K., Miwa H., Rokushima M., Yoshinaga T., Tanaka T., Togame T., Takemoto H., Amano M., Iwasaki N.,Minami A and Nishimura S-I., “Discovery of novel differentiation markers in the early stage of chondrogenesis by glycoform-focused reverse proteomics and genomics”, BBA-GenSubjects 1840, 645-655 (2014)

316

Miyahara K., Nouso K., Miyake Y., Nakamura S., Obi S., Amano M., Hirose K., Nishimura S-I and Yamamoto K., Serum glycan as a prognostic marker in patients with advanced hepatocellular carcinoma treated with sorafenib”, Hepatology 59, 355-356 (2014)

315

Nakagawa S., Shimamura S., Takaki Y., Suzuki Y.,  Murakami S., Watanabe T., Fujiyoshi S., Mino S.,  Sawabe T., Maeda T., Makita H., Nemoto S.,  Nishimura S-I., Watanabe H., Watsuji T andTakai K, “Allying with armored snails: the complete genome of gammaproteobacterialendosymbiont.”, ISME J. 8, 40-51 (2014)

314 Hatakeyama S., Amano M., Tobisawa Y., Yoneyama T., Tsushima M., Hirose K., Yoneyama T., Hashimoto Y., Koie T., Saitoh H., Yamaya K., Funyu T., Nisimura S-I and Ohyama C., “Serum N-glycan profiling predicts prognosis in patients undergoing hemodialysis”, Sci. World J. 2013, ID268407 (2013)

313

Takeuchi M., Amano M., Kitamura H., Tsukamoto T., Masumori N., Hirose K., Ohashi T and Nishimura S-I., “N- and O-glycome analysis of serum and urine from bladder cancer patients using a high-throughput glycoblotting method, Journal of Glycomics & Lipidomics 3, 108 (2013)

312

Kumar R., Naruchi K., Miyoshi R., Hinou H and Nishimura S-I., “A New Approach for the Synthesis of Hyper-Branched N-Glycan Core Structures from Locust Bean Gum”, Org. Lett. 15, 6278-6281 (2013)

311

Miyahara K., Nouso K., Saito S., Hiraoka S., Harada K., Takahashi S., Morimoto Y., Kobayashi S., Ikeda F., Miyake Y., Shiraha H., Takaki A., Amano M., Nishimura S.-I, Yamamoto K., Serum glycan markers for evaluation of disease activity and prediction of clinical course in patients with ulcerative colitis., PLOS ONE  8, e74861 (2013)

310

Hideshima S., Hinou H., Ebihara D., Sato R., Kuroiwa S., Nakanishi T., Nishimura S-I., Osaka T., Attomolar Detection of Influenza A Virus Hemagglutinin Human H1 and Avian H5 Using Glycan-blotted Field Effect Transistor Biosensor”, Anal. Chem. 85, 5641-5644 (2013)

309

Feng F., Sakoda Y., Ohyanagi T., Nagahori N., Shibuya H., Okamastu M., Miura N., Kida H., Nishimura S-I., Novel thiosialosides tethered to metal nanoparticles as potent influenza A virus hemagglutinin blockers”, Antivir. Chem. Chemoth. 23, 59-65 (2013)

308

Nouso K., Amano M., Miyahara K., Ito M. Y., Miyahara K., Morimoto Y., Kato H., Tsutsumi K., Tomoda T., Yamamoto N., Nakamura S., Kobayashi S., Kuwaki K., Hagihara H., Onishi H., Miyake Y., Ikeda F., Shiraha H., Takaki A., Nakahara T., Nishimura S-I., Yamamoto K., “Clinical utility of high-throughput glycome analysis in patients with pancreatic cancer”, J. Gastroenterology 48, 1171-1179 (2013)

307

Matsushita T., Ohyabu N., Fujitani N., Naruchi K., Shimizu H., Hinou H., Nishimura S-I.,  Site-specific conformational alteration induced by sialylation of MUC1 tandem repeating glycopeptides at an epitope region for anti-KL-6 monoclonal antibody”, Biochemistry 52, 402-414 (2013)

306

Kamiyama T., Yokoo H., Furukawa J., Kurogochi M., Togashi T., Miura N., Nakanishi K., Kamachi H., Kakisaka T., Tsuruga Y., Taketomi A., Nishimura S-I., Todo S., “Identification of novel serum biomarkers of hepatocellular carcinoma using glycomic analysis”, Hepatology 57, 2314-2325 (2013)

305

Matsushita T., Handa S., Naruchi K., Garcia-Martin F., Hinou H., Nishimura S-I., “A novel approach for the parallel synthesis of glycopeptides by combining solid-phase peptide synthesis and dendrimer-supported enzymatic modifications”, Polym.J. 45, 854-862 (2013)

304

Izumi R., Matsushita T., Fujitani N., Naruchi K., Shimizu H., Tsuda S., Hinou H., Nishimura S-I., “Microwave-assisted solid-phase synthesis of antifreeze glycopeptides”, Chem. Eur. J. 19, 3913-3920 (2013)

303

Okamatsu M., Feng F., Ohyanagi T., Nagahori N., Someya K., Sakoda Y., Miura N., Nishimura S-I., Kida H.,“Fluorescence polarization-based assay using N-glycan-conjugated quantum dots for screening in hemagglutinin blockers for influenza A viruses”, J. Virol. Methods 187, 390-394 (2013)

302

Furukawa T., Arai M., Garcia-Martin F., Amano M., Hinou H., Nishimura S-I., Glycoblotting-based high throughput protocol for the structural characterization of hyaluronan degradation products during enzymatic fragmentation”, Glycoconjugate J. 30, 171-182 (2013)

301

Kai H., Hinou H., Naruchi K., Matsushita T., Nishimura S-I., Macrocyclic Mechanism-based Inhibitor for Neuraminidases”, Chem. Eur. J. 19, 1364-1372 (2013)

300

Nagahori N., Yamashita T., Amano M., Nishimura S-I.,Effect of ganglioside GM3 synthase gene knockout on the glycoprotein N-glycan profile of mouse embryonic fibroblast”, ChemBioChem 14, 73-82 (2013)

299

Kimura K., Tanaka I., Nishimura S-I., Miyoshi R., Miyoshi T., Watanabe Y.,Further examination of polysaccharides causing membrane fouling in membrane bioreactors (MBRs): Application of lectin affinity chromatography and MALDI-TOF/MS”, Water Res. 46, 5725-5734 (2012)

298

Manri N., Takegawa Y., Fujitani N., Kaneko A., Hirabayashi A., Nishimura S-I., Sakamoto T., Determination of O-Glycosylation Heterogeneity Using a Mass-Spectrometric Method Retaining Sugar Modifications”, Anal. Sci. 28, 723-727 (2012)

297

Amano M., Eriksson H, Manning J.C., Detjen K. M., André S., Nishimura S-I, Lehtiö J., and Gabius H.-J., Tumor suppressor p16INK4a: anoikis-favoring decrease in N/O-glycan/cell surface sialylation by downregulation of enzymes in sialic acid biosynthesis in tandem in a pancreatic carcinoma model”, FEBS J.  279, 4062-4080 (2012) 

296

Furukawa T., Hinou H, Nishimura S-I.,Strict Stereocontrol by 2,4-O-Di-tert-butylsilylene Group on β-Glucuronylations”, Org. Lett. 14, 2102-2105 (2012)

295

Kai H, Hinou H, Nishimura S-I., Aglycone-focused randomization of 2-difluoromethylphenylsialoside-type suicide substrates for neuraminidases”, Bioorgan. Med. Chem. 20, 2739-2746 (2012)

294 

Nishimura S-I., Hato M., Hyugaji S., Feng F., and Amano M., Glycomics for drug discovery: Metabolic perturbation in androgen-independent prostate cancer cells induced by unnatural hexosamine mimics, Angew. Chem. Int. Ed. 51, 3386-3390 (2012)

293 

Hoshi H., Shimawaki K., Takegawa Y., Ohyanagi T., Amano M., Hinou H., and Nishimura S-I., Molecular shuttle between extracellular and cytoplasmic space allows for monitoring of GAG biosynthesis in human articularchondrocytes, Biochim. Biophys. Acta 1820, 1391-1398 (2012) 

292 

Garcia-Martin F., Hinou H., Matsushita T., Hayakawa S., and Nishimura S-I., An efficient protocol for the solid-phase synthesis of glycopeptides under microwave irradiation, Org. Biomol. Chem. 10, 1612-1617 (2012) 

291

Yoshimura Y., Aaron S. Nudelman., Steven B. Levery., Hans H. Wandall., Eric P. Bennett., Ole Hindsgaul., Henrik Clausen and Nishimura S-I.,Elucidation of the sugar recognition ability of the lectin domain of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3 by using unnatural glycopeptide substrates, Glycobiology 22, 429-438 (2012)

290 

Abe M., Shimaoka H., Fukushima M., and Nishimura S-I., A cross-linked polymer possessing a high density of hydrazide groups: High-throughput glycan purification and labeling for high-performance liquid chromatography analysis, Polym. J. 44, 269-277(2012) 

289 

Amano M., Hashimoto R., and Nishimura S-I., Effects of single genetic damage in carbohydrate recognizing proteins on mouse serum N-glycan profile revealed by a simple glycotyping analysis, ChemBioChem. 13, 451-464 (2012) 

288 

Takimori S., Shimaoka H., Furukawa J-i., Yamashita T., Amano M., Fujitani N., Takegawa Y., Hammarstrom L., Kacskovics I., Shinohara Y., and Nishimura S-I., Alteration of the N-glycome of bovine milk glycoproteins during early lactation , FEBS J. 278, 3769-3781 (2011) 

287 

Furukawa T., Hinou H., Shimawaki K., Nishimura S-I., “A potential glucuronateglycosyl donor with 2-O-acyl-6,3-lactone structure: efficient synthesis of glycosaminoglycan disaccharides”, TetrahedoronLett. 52, 5567-5570 (2011) 

286 

Hinou H., Saito N., Maeda T., Matsuda M., Kamiya Y., and Nishimura S-I., “Toward Green and Sustainable Chemical Glycosylation: Enhanced Lewis Acidity of Recyclable Solid Super Acid Catalyst, SO4/ZrO2 by CaC12 Dpoing”, J. Carbohyd. Chem. 30, 575-586 (2011) 

285 

Ohyanagi T., Nagahori N., Shimawaki K., Hinou H., Yamashita T., Sasaki A., Jin T., Iwanaga T., Kinjo M., and Nishimura S-I., Importance of sialic acid residues illuminaterd by live animal imaging using phosphorylcholine self-assembled monolayers-coated quantum dots, J. Am. Chem. Soc. 133, 12507-12517(2011) 

284 

Ishihara T., Fukuda I., Morita A., Takinami Y., Okamoto H., Nishimura S-I., and Numata Y., Development of quantitative plasma N-glycoproteomics using label-free 2-D LC-MALDI MS and its applicability for biomarker discovery in hepatocellular carcinoma, J. Proteomics 74, 2159-2168 (2011) 

283 

Urita A., Matsuhashi T., Onodera T., Nakagawa H., Hato M., Amano M., Seito N., Minami A., and Nishimura S-I., Alterations of High-mannose Type N-Glycosylation in Human and Mouse Ostesarthritis Cartilage, Arthritis & Rheumatism 63, 3428-3438 (2011) 

282 

Hirose K., Amano M., Hashimoto R., Yuan L and Nishimura S-I., “Insight into glycan diversity and evolutionary lineage based on comparative avio-N-glycomics and sialic acids analysis of 88 egg whites of Galloanserae, Biochemistry 50, 4757-4774 (2011) 

281 

Hinou H., Miyoshi R., Takasu Y., Kai H., Kurogochi M., Arioka S., Gao X-D., Miura N., Fujitani N., Otomo S., Yoshinaga T., Fujiwara T., Noshi T., Togame H., Takemoto H., and Nishimura S-I., A Strategy for Neuraminidase Inhibitors Using Mechanism-Based Labeling Information, Chem. Asian J. 6, 1048-1056 (2011) 

280 

Naruchi K., and Nishimura S-I., Membrane-Bound Stable Glycosyltransferases: Highly Oriented Protein Immobilization by a C-Terminal Cationic Amphipathic Peptide, Angew. Chem. Int. Ed. 80, 1328-1331 (2011) 

279 

Hashimoto R., Fujitani N., Takegawa Y., Kurogochi M., Matsushita T., Naruchi K., Ohyabu N., Hinou H., Gao X-D., Manri N., Satake H., Kaneko A., Sakamoto T., and Nishimura S-I., An efficient approach for the characterization of mucin type glycopeptides: The effect of O-glycosylation on the conformation of synthetic mucin peptides, Chem. Eur. J. 17, 2393-2404 (2011) 

278 

Irie T., Majima T., Sawaguchi N., Funakoshi T., Nishimura S-I., and Minami A., Biomechanical and histologic evaluation of tissue enjinnered ligaments using chitosan and hyaluronan hybrid polymer fibers: A rabbit medial collateral ligament reconstruction model, J. Biomed. Mater. Res. Part A 97A, 111-117(2011) 

277 

Miura Y., Kato K., Takegawa Y., Kurogochi M., Furukawa J.-i., Shinohara Y., Nagahori N., Amano M., Hinou H., and Nishimura S-I., Glycoblotting-assisted O- glycomics:Ammoniumcarbamate allows for highly efficient O-glycan release from glycoproteins, Anal. Chem. 82, 10021-10029 (2010) 

276 

Matsushita T., Nagashima I., Fumoto M., Ohta T., Yamada K., Shimizu H., Hinou H., Naruchi K., Ito T., Kondo H., and Nishimura S-I., Artificial Golgi apparatus: Globular protein-like dendrimer facilitates fully automated enzymatic glycan synthesis, J. Am. Chem. Soc. 132, 16651-16656 (2010) 

275 

Ueda T., Ito T., Tomita K., Togame H., Fumoto M., Asakura K., Oshima T., Nishimura S-I., and Hanasaki K., Identification of glycosylated exendin-4 analogue with prolonged blood glucose-lowering activity through glycosylation scanning substitution, Bioorg. Med. Chem. Lett. 20, 4631-4634 (2010) 

274 

Shimizu H. K., Hosoguchi K., Liu Y., Fujitani N., Ohta T., Hinou H., Matsushita T., Shimizu H., Feizi T., and Nishimura S-I., Chemical synthesis, folding and structural insights into O-fucosylated epidermal growth factor-like repeat 12 of mouse Notch-1 receptor, J. Am. Chem. Soc. 132, 14857-14865 (2010) 

273

Hosoguchi K., Maeda T., Furukawa J.-i., Shinohara Y., Hinou H., Sekiguchi M., Togame H., Takemoto H., Kondo H., and Nishimura S-I., An Efficient Approach to the Discovery of Potent Inhibitors against Glycosyltransferases, J. Med. Chem. 53, 5607-5619 (2010) 

272

Hashimoto R., Hirose K., Sato T., Fukushima N., Miura N., and Nishimura S-I., Functional network of glycan-related molecules: Glyco-Net in Glycoconjugate Data Bank, BMC. Syst. Biol. 4, 91 (2010)  

271 

Kurogochi M., Matsushita T., Amano M., Furukawa J.-i., Shinohara Y., Aoshima M., and Nishimura S-I., Sialic acid-focused quantitative mouse serum glycoproteomics by multiple reaction monitoring assay, Mol. Cell. Proteomics. 9, 2354-2368 (2010) 

270 

Yoshimura Y., Matsushita T., Fujitani N., Takegawa Y., Fujihira H., Naruchi K., Gao, X-D., Manri N., Sakamoto T., Kato K., Hinou H., and Nishimura S-I., Unexpected Tolerance of Glycosylation by UDP-GalNAc:Polypeptide alpha-N-Acetylgalactosaminyltransferase Revealed by Electron Capture Dissociation Mass Spectrometry: Carbohydrate as Potential Protective Groups, Biochemistry 49, 5929-5941 (2010) 

269 

Feng F., Miura N., Isoda N., Sakoda Y., Okamatsu M., Kida H., and Nishimura S-I., Novel trivalent anti-influenza reagent, Bioorg. Med. Chem. Lett. 20, 3772-3776 (2010) 

268 

Carvalho S., Sola-Penna M., Oliveira I., Pita S., Goncalves A., Neves B., Sousa F., Freire-de-Lima., Kurogochi M., Hinou H., Nishimura S-I., Previato J., and Todeschini A., A new class of mechanism-based inhibitors for Trypanosamacruzi trans-sialidase and their influence on parasite virulence, Glycobiology 20, 1034-1045 (2010) 

267 

Ito T, Sadamoto R., Naruchi K., Togame H., Takemoto H., Hondo H., and Nishimura S-I., Highly Oriented Recombinant Glycosyltransferases: Site-Specific Immobilization of Unstable Membrane Proteins by using Staphylococcus aureusSortase A, Biochemistry 49, 2604-2614 (2010) 

266 

Kimura A., Tandang M.-R., Fukuda T., Cabanos C., Takegawa Y., Amano M., Nishimura S-I., Matsumura Y., Maruyama N., and Utsumi S., Carbohydrate moieties contribute significantly to the excellent physicochemical properties of French bean 7S globulin phaseolin, J. Agric. Food. Chem. 58, 2923-2930 (2010) 

265 

Arioka S., Sakagami M., Uematsu R., Yamaguchi H., Togame H., Takemoto H., Hinou H., and Nishimura S-I., Potent inhibitor scaffold against Trypanosomacruzi trans-sialidase, Bioorgan. Med. Chem. 18, 1633-1640 (2010) 

264 

Amano M., Yamaguchi M., Takegawa Y., Yamashita T., Terasima M., Furukawa J.-i., Miura Y., Shinohara Y., Iwasaki N., Minami A., and Nishimura S-I., “Threshold in Stage Specific Embryonic Glycotypes Uncovered by a Full Portrait of Dynamic N-Glycan Expression during Cell Differentiation”, Mol. Cell. Proteomics. 9, 523-537 (2010) 

 

This publication list only displays the ones published after 2010.
2010
年以降の論文を載せています。