論文(一部)

  • Nakamura K, Yokoi Y, Fukaya R, Ohira S, Shinozaki R, Nishida T, Kikuchi M, Ayabe T. Expression and localization of Paneth cells and their α-defensins in the small intestine of adult mouse. Front Immunol 2020. 11: 570296. doi: 10.3389/fimmu.2020.570296.
  • Hanyu H, Yokoi Y, Nakamura K, Ayabe T, Tanaka K, Uno K, Miyajima K, Saito Y, Iwatsuki K, Shimizu M, Tadaishi M, Kobayashi-Hattori K. Mycotoxin deoxynivalenol has different impacts on intestinal barrier and stem cells by its route of exposure. Toxins 2020. 12: 610. doi: 10.3390/toxins12100610.
  • Shimizu Y, Nakamura K, Yoshii A, Yokoi Y, Kikuchi M, Shinozaki R, Nakamura S, Ohira S, Sugimoto R, Ayabe T. Paneth cell α-defensin misfolding correlates with dysbiosis and ileitis in Crohn’s disease model mice. Life Science Alliance 2020. doi: 10.26508/lsa.201900592.
  • Komatsu Y, Shimizu Y, Yamano M, Kikuchi M, Nakamura K, Ayabe T, Aizawa T. Disease progression-associated alterations in fecal metabololies in SAMP1/YitFc mice, a Crohn’s disease model. Metabolomics 2020. 16: 48. doi: 10.1007/s11306-020-01671-5.
  • Hirabayashi Y, Nakamura K, Sonehara T, Suzuki D, Hanzawa S, Shimizu Y, Aizawa T, Nakamura K, Tamakoshi A, Ayabe T. Analysis of serotonin in human feces using solid phase extraction and column-switching LC-MS/MS. Mass Spectrometry 2020. doi: 10.5702/massspectrometry.A0081.
  • Takakuwa A, Nakamura K, Kikuchi M, Sugimoto R, Ohira S, Yokoi Y, Ayabe T. Butyric acid and leucine induce a-defensin secretion from small intestinal Paneth cells. Nutrients 2019, 11(11), 2817; doi: 10.3390/nu11112817.
  • Yamamura R, Nakamura K, Kitada N, Aizawa T, Schimizu Y, Nakamura K, Ayabe T, Kimura T, Tamakoshi A. Associations of gut microbiota, dietary intake, and serum short-chain fatty acids with fecal short-chain fatty acids. Biosci Microbiota Food Health 2019, doi.org/10.12938/bmfh.19-010.
  • Shimizu Y, Sakuragi N, Nakamura K, Taira T, Ayabe T, Fukui A. A simple culture method for liver and intestinal tissue-resident macrophages from neonatal mice. In Vitro Cell Dev Biol Anim doi.org/10.1007/s11626-019-00359-y
  • Yokoi Y, Nakamura K, Yoneda T, Kikuchi M, Sugimoto R, Shimizu Y, Ayabe T. Paneth cell granule dynamics on secretory responses to bacterial stimuli in enteroids. Sci Rep doi.org/10.1038/s41598-019-39610-7.
  • Pillai MR, Mihi B, Ishiwata K, Nakamura K, Sakuragi N, Finkelstein DB, McGargill MA, Nakayama T, Ayabe T, Coleman ML, Bix M. Myc-induced nuclear antigen constrains a latent intestinal epithelial cell-intrinsic anthelmintic pathway. PLOS ONE doi: 10.1038/s41598-019-39610-7.
  • Eriguchi Y, Nakamura K, Yokoi Y, Takahashi S, Hashimoto D, Teshima T, Ayabe T, Selsted ME, Ouellette AJ. Essential role of interferon-gamma in T cell-associated intestinal inflammation. JCI Insight 2018. 3(18): e121886. doi.org/10.1172/jci.insight.121886.
  • Yaguchi K, Yamamoto T, Shimada M, Sugimoto R, Nakamura K, Ayabe T, Uehara R. Ploidy-dependent change in cyclin D2 expression and sensitization to cdk4/6 inhibition in human somatic haploid cells. Biochem Biophys Res Commun 2018. doi.org/10.1016/j.bbrc.2018.08.160.
  • Cobo ER, Holani R, Moreau F, Nakamura K, Ayabe T, Mastroiannid JR, Ouellette AJ, Chadee K. Entamoeba histolytica alters ileal Paneth cell functions in intact and Muc2 mucin deficiency. Infect Immun2018. doi: 10.1128/IAI.00208-18.
  • Hayase E, Hashimoto D, Nakamura K, Noizat C, Ogasawara R, Takahashi S, Ohigashi H, Yokoi Y, Sugimoto R, Matsuoka S, Ara T, Yokoyama E, Yamakawa T, Ebata K, Kondo T, Hiramine R, Aizawa T, Ogura Y, Hayashi T, Mori H, Kurokawa K, Tomizuka K, Ayabe T, Teshima T. R-Spondin1 expands Paneth cells and prevents dysbiosis induced by graft-versus-host disease. J Exp Med doi: 10.1084/jem.20170418.
  • Nohara S, Kato K, Fujiwara D, Sakuragi N, Yanagihara K, Iwanuma Y, Kajiyama Y. Aminopeptidase N (APN/CD13) as a target molecule for scirrhous gastric cancer. Clin Res Hepatol Gastroenterol 40: 494-503, 2016.
  • Nakamura K, Sakuragi N, Takakuwa A, Ayabe T. Paneth cell α-defensins and enteric microbiota in health and disease. Biosci Microbiota Food Health 35: 57-67, 2016.
  • Nohara S, Kato K, Fujiwara D, Sakuragi N, Yanagihara K, Iwanuma Y, Kajiyama Y. Aminopeptidase N (APN/CD13) as a target molecule for scirrhous gastric cancer. Clin Res Hepatol Gastroenterol 40: 494-503, 2016.
  • Nukuda A, Sasaki C, Ishihara S, Mizutani T, Nakamura K, Ayabe T, Kawabata K, Haga H. Stiff substrates increase YAP-signaling-mediated matrix metalloproteinase-7 expression. Oncogenesis 4: e165, 2015.
  • Eriguchi Y, Nakamura K, Hashimoto D, Shimoda S, Shimono N, Akashi K, Ayabe T, Teshima T. Decreased Secretion of Paneth cell α-defensin in Graft-versus-host disease. Transpl Infect Dis 17: 702-706, 2015.
  • Tomisawa S, Sato Y, Kamiya M, Kumaki Y, Kikukawa T, Kawano K, Demura M, Nakamura K, Ayabe T, Aizawa T. Efficient production of a correctly folded mouse α-defensin, cryptdin-4, by refolding during inclusion body solubilization. Protein Expr Purif 112: 21-28, 2015.
  • Taira R, Yamaguchi S, Shimizu K, Nakamura K, Ayabe T, Taira T. Bacterial cell wall components regulate adipokine secretion from visceral adipocytes. J Clin Biochem Nutr 56: 149-154, 2015.
  • Ikeda M, Yamaguchi M, Kato K, Nakamura K, Shiina S, Ichikawa-Ando T, Misaka H, Myojo K, Nakamura K, Sugimoto Y, Hamada H. Pr1E11, a novel anti-TROP-2 antibody isolated by adenovirus-based antibody screening, recognizes a unique epitope. Biochem Biophys Res Commun 458: 877-882, 2015.
  • Yamaguchi M, Nishii Y, Nakamura K, Aoki H, Hirai S, Uchida H, Sakuma Y, Hamada H. Development of a sensitive screening method for selecting monoclonal antibodies to be internalized by cells. Biochem Biophys Res Commun 454: 600-603, 2014.
  • Nakamura K, Sakuragi N, Ayabe T. A monoclonal antibody-based sandwich enzyme-linked immunosorbent assay for detection of secreted α-defensin. Anal Biochem 443: 124-131, 2013.
  • Eriguchi Y, Uryu H, Nakamura K, Shimoji S, Takashima S, Iwasaki H, Miyamoto T, Shimono N, Hashimoto D, Akashi K, Ayabe T, Teshima T. Reciprocal expression of enteric antimicrobial proteins in intestinal graft-versus-host disease. Biol Blood Marrow Transplant 19: 1525-1529, 2013.
  • Takemoto K, Matsuda T, Sakai N, Fu D, Noda M, Uchiyama S, Kotera I, Arai Y, Horiuchi M, Fukui K, Ayabe T, Inagaki F, Suzuki H, Nagai T. SuperNova, a monomeric photosensitizing fluorescent protein for chromophore-assisted light inactivation. Sci Rep 3: 026291-026297, 2013.
  • Tanaka M, Kuribayashi K, Kogawa K, Nakamura K, Watanabe N. Intracellular superoxide dismutase activity defines invasiveness of the murine T-lymphoma cell line L5187Y-ML25 in vitro and in vivo. Leuk Res 37: 89-92, 2013.
  • Eriguchi Y, Takashima S, Oka H, Shimoji S, Nakamura K, Uryu H, Shimoda S, Iwasaki H, Shimono N, Ayabe T, Akashi K, Teshima T. Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of α -defensins. Blood 120: 223-231, 2012.
  • Ito T, Tanabe H, Ayabe T, Ishikawa C, Inaba Y, Maemoto A, Kono T, Ashida T, Fujiya M, Kohgo Y. Paneth cells regulate both chemotaxis of immature dendritic cells and cytokine production from epithelial cells. Tohoku J Exp Med 227: 39-48, 2012.
  • Konno Y, Ashida T, Inaba Y, ItoT, Tanabe H, Maemoto A, Ayabe T, Mizukami Y, Fujiya M, Kohgo Y. Isoleucine, an Essential Amino Acid, Induces the Expression of Human β Defensin 2 through the Activation of the G-Protein Coupled Receptor-ERK Pathway in the Intestinal Epithelia. Food Nutrition Sciences 3: 548-555, 2012.
  • Sato Y, Tomisawa S, Aizawa T, Sakai N, Kamiya M, Kikukawa T, Kumaki Y, Demura M, Ayabe T, Kawano K. Conststruction of a novel expression system for cryptdin-4 by using inclusion body formation. Peptide Science 2011 393-394, 2012.
  • Nakamura K, Ayabe T. Paneth cells and stem cells in the intestinal stem cell niche and their association with inflammatory bowel disease.
    Inflammation Regeneration 32: 53-60, 2012.
  • Masuda K, Nakamura K, Yoshioka S, Fukaya R, Sakai N, Ayabe T. Regulation of microbiota by antimicrobial peptides in the gut.
    Adv Otorhinolaryngol 72: 97-99, 2011.
  • Masuda K, Sakai N, Nakamura K, Yoshioka S, Ayabe T. Bactericidal activity of mouse α-defensin, cryptdin-4 predominantly affects non-commensal bacteria.
    J Innate Immun 3: 315-326, 2011.
  • Son SH, Abe Y, Yuasa M, Yamagishi Y, Sakai N, Ayabe T, Yamada K. A systematic analysis of aromatic heterocyclic rings in solvatochromic fluorophores.
    Chem Lett 40(4): 378-380, 2011.
  • Kawaguchi A, Suzuki T, Sakai N, Kimura T, Ayabe T, Hasegawa H, Sawa H. Functional analysis of an α-helical antimicrobial peptide derived from a novel mouse defensin-like gene.
    Biochm Biophys Res Commun 398: 778-784, 2010.
  • Inaba Y, Ashida T, Ito T, Ishikawa C, Tanabe H, Maemoto A, Watari J, Ayabe T, Mizukami Y, Fujiya M, Kohgo Y. Expression of the antimicrobial peptide α-defensin/cryptdins in intestinal crypts decreases at the initial phase of intestinal inflammation in a model of inflammatory bowel disease, IL-10-deficient mice.
    Inflamm Bowel Dis 16: 1488-1495, 2010.
  • Ishikawa C, Tanabe H, Maemoto A, Ito T, Watari J, Kono T, Fujiya M, Ashida T, Ayabe T, Kohgo Y. Precursor processing of human defensin-5 is essential to the multiple functions in vitro and in vivo.
    J Innate Immun 2: 66-76, 2010.
  • Tamura S, Amano S, Kono T, Kondoh J, Yamaguchi K, Kobayashi S, Ayabe T, Moriyama T. Molecular characteristics and physiological functions of major royal jelly protein 1 oligomer.
    Proteomics 9: 5534-5543, 2009.
  • Tanabe H, Sato T, Watari J, Maemoto A, Fujiya M, Kono T, Ashida T, Ayabe T, Kohgo Y. Functional role of metaplastic Paneth cell defensins in Helicobacter pylori-infected stomach.
    Helicobacter 13: 370-379, 2008.
  • Sakai N, Ayabe T. Antimicrobial peptides in the gut innate immunity.
    Int J Probiotics Prebiotics 3: 123-126, 2008.
  • Tanabe H, Ayabe T, Maemoto A, Ishikawa C, Inaba Y, Sato R, Moriichi K, Okamoto K, Watari J, Kono T, Ashida T, Kohgo Y. Denatured human α-defensin attenuates the bactericidal activity and the stability against enzymatic digestion.
    Biochm Biophys Res Commun 358: 349-355, 2007.
  • Tanabe H, Ayabe T, Bainbridge B, Guina T, Ernst RK, Darveau RP, Miller SI, Ouellette AJ. Mouse Paneth cell responses to cell surface glycolipids of virulent and attenuated pathogenic bacteria.
    Infect Immun 73: 2312-2320, 2005.
  • Ayabe T, Ashida T, Kohgo Y, Kono T. The role of Paneth cells and their antimicrobial peptides in innate host defense.
    Trends Microbiol 12: 394-398, 2004.
  • Kohgo Y, Ashida T, Maemoto A, Ayabe T. Leukocytapheresis for treatment of IBD.
    J Gastroenterol [Suppl XV]: 31-34, 2003.
  • Ayabe T, Satchell DP, Pesendorfer P, Tanabe H, Wilson CL, Hagen SJ, Ouellette AJ. Activation of Paneth cell α-defensins in mouse small intestine.
    J Biol Chem 277: 5219-5228, 2002.
  • Ayabe T, Wulff H, Darmoul D, Cahalan MD, Chandy KG, Ouellette AJ. Modulation of mouse Paneth cell α-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance Potassium channel.
    J Biol Chem 277: 3793-3800, 2002.
  • Ayabe T, Satchell DP, Wilson CW, Parks WC, Selsted ME, Ouellette AJ. Secretion of microbicidal α-defensins by intestinal Paneth cells in response to bacteria.
    Nature Immunol 1: 113-118, 2000.
  • Honda M, Orii F, Ayabe T, Imai S, Ashida T, Obara T, Kohgo Y. Expression of glucocorticoid receptor β in lymphocytes of patients with glucocorticord-resistant ulcerative colitis.
    Gastroenterology 118: 859-866, 2000.
  • Wilson CL, Ouellette AJ, Satchell DP, Ayabe T, Lopez-Boado YS, Stratman JL, Hultgren SJ, Matrisian LM, Parks WC. Regulation of intestinal α-defensin activation by the metalloproteinase matrilysin in innate host defense.
    Science 286: 113-117, 1999.