{"id":17,"date":"2012-05-22T17:56:29","date_gmt":"2012-05-22T08:56:29","guid":{"rendered":"http:\/\/h2.tank.jp\/lfsci\/1000\/?page_id=17"},"modified":"2025-07-05T16:26:31","modified_gmt":"2025-07-05T07:26:31","slug":"performance","status":"publish","type":"page","link":"https:\/\/altair.sci.hokudai.ac.jp\/infsig\/performance\/","title":{"rendered":"\u696d\u7e3e"},"content":{"rendered":"<h1>\u8ad6\u6587(\u4e00\u90e8)<\/h1>\n<ul>\n<li>Shimizu Y, Yokoi Y, Ohira S, Izumi H, Kawakami S, Ihara M, Tabata F, Takeda Y, Kimura T, Nakamura K, Tamakoshi A, Ayabe T, Nakamura K. Modulation of Bifidobacterium by HD5 during weaning is associated with high abundance in later life. <strong><em>Commun Med <\/em><\/strong>2025. 5(1):250. doi: 10.1038\/s43856-025-00977-6.<\/li>\n<li>\n<div draggable=\"false\" data-pm-slice=\"1 1 []\" data-en-clipboard=\"true\">Yan S, Gu H, Shibagaki M, Chrisnanto JO, Hirai F, Kumeta H, Kumaki Y, Yokoi Y, Nakamura K, Kikukawa T, Ayabe T, Arai T, Aizawa T. Recombinant Production of Isotope-labeled Human \u03b1-Defensin 5 via Calmodulin Fusion and Insights into Its Expression Enhancement. <em><strong>Peptides <\/strong><\/em>2025. doi: 10.1016\/j.peptides.2025.171425.<\/div>\n<\/li>\n<li>\n<div data-pm-slice=\"1 1 []\" data-en-clipboard=\"true\">Yokoi Y, Nakamura R, Ohira S, Takemi S, Ayabe T, Nakamura K. Potential consequences of phototoxicity on cell function during live imaging of intestinal organoids. <b><i>PLoS One <\/i><\/b>2024. 19(11):e0313213. doi: 10.1371\/journal.pone.0313213.<\/div>\n<\/li>\n<li>\n<div data-pm-slice=\"1 1 []\" data-en-clipboard=\"true\">Yonoichi S, Hara Y, Ishida Y, Shoda A, Kimura M, Murata M, Nunobiki S, Ito M, Yoshimoto A, Mantani Y, Yokoyama T, Hirano T, Ikenaka Y, Yokoi Y, Ayabe T, Nakamura K, Hoshi N. Effects of exposure to the neonicotinoid pesticide clothianidin on \u03b1-defensin secretion and gut microbiota in mice. <em><strong>J Vet Med Sci <\/strong><\/em>2024. 1;86(3):277-284. doi: 10.1292\/jvms.23-0514.<\/div>\n<\/li>\n<li>Gan L, Inamura Y, Shimizu Y, Yokoi Y, Ohnishi Y, Song Z, Kumaki Y, Kikukawa T, Demura M, Ito M, Ayabe T, Nakamura K, Aizawa T. A Basic Study of the Effects of Mulberry Leaf Administration to Healthy C57BL\/6 Mice on Gut Microbiota and Metabolites. <strong><em>Metabolites<\/em><\/strong>\u00a02023. 10;13(9):1003. doi: 10.3390\/metabo13091003.<\/li>\n<li>\n<div data-pm-slice=\"1 1 []\" data-en-clipboard=\"true\">\n<div data-pm-slice=\"1 1 []\" data-en-clipboard=\"true\">Wang Y, Song Y, Yan S, Hiramine R, Ohnishi Y, Yokoi Y, Nakamura K, Kikukawa T, Ayabe T, Aizawa T. Antimicrobial Properties and Mode of Action of Cryptdin-4, a Mouse \u03b1-Defensin Regulated by Peptide Redox Structures and Bacterial Cultivation Conditions. <b><i>Antibiotics <\/i><\/b>2023. 12(6), 1047. doi: 10.3390\/antibiotics12061047<\/div>\n<\/div>\n<\/li>\n<li>\n<div data-pm-slice=\"1 1 []\" data-en-clipboard=\"true\">Song Z, Ohnishi Y, Osada S, Gan L, Jiang J, Hu Z, Kumeta H, Kumaki Y, Yokoi Y, Nakamura K, Ayabe T, Yamauchi K, Aizawa T. Application of Benchtop NMR for Metabolomics Study Using Feces of Mice with DSS-Induced Colitis. <b><i>Metabolites <\/i><\/b>2023. 28;13(5):611. doi: 10.3390\/metabo13050611<\/div>\n<\/li>\n<li>Shimizu Y, Yamamura R, Yokoi Y, AyabeT, Ukawa S, Nakamura K, Okada E, Imae A, Nakagawa T, Tamakoshi A, Nakamura K. Shorter sleep time relates to lower human defensin 5 secretion and compositional disturbance of the intestinal microbiota accompanied by decreased short-chain fatty acid production. <strong><em>Gut Microbes<\/em><\/strong> 2023. doi: 10.1080\/19490976.2023.2190306<\/li>\n<li>Nakamura S, Nakamura K, Yokoi Y, Shimizu Y, Ohira S, Hagiwara M, Song Z, Gan L, Aizawa T, Hashimoto D, Teshima T, Ouellette AJ, Ayabe T. Decreased Paneth cell a-defensins promote fibrosis in a choline-deficient L-amino acid-defined high-fat diet-induced mouse model of nonalcoholic steatohepatitis via disrupting intestinal microbiota. <strong><em>Sci Rep<\/em><\/strong> 2023. 13: 3953. doi: 10.1038\/s41598-023-30997-y<\/li>\n<li>Komatsu Y, Wada Y, Tabata F, Kawakami S, Takeda Y, Nakamura K, Ayabe T, Nakamura K, Kimura T, Tamakoshi A. Associations between Maternal Diet, Human Milk Macronutrients, and Breast-Fed Infant Growth during the First Month of Life in the SMILE Iwamizawa in Japan. <strong><em>Nutrients<\/em><\/strong> 2023. 15(3):654. doi: 10.3390\/nu15030654<\/li>\n<li>Song Y, Wang Y, Yan S, Nakamura K, Kikukawa T, Ayabe T, Aizawa T. Efficient recombinant production of mouse-derived cryptdin family peptides by a novel facilitation strategy for inclusion body formation. <strong><em>Microb Cell Fact<\/em><\/strong> 2023. 22(1):9. doi: 10.1186\/s12934-023-02016-2<\/li>\n<li>Ohira S, Yokoi Y, Ayabe T, Nakamura K. Efficient and simple genetic engineering of enteroids using mouse isolated crypts for investigating intestinal functions. <strong><em>Biochem Biophys Res Commun<\/em><\/strong> 2022. 637:153-160. doi: org\/10.1016\/j.bbrc.2022.11.008<\/li>\n<li>Chen X, Hashimoto D, Ebata K, Takahashi S, Shimizu Y, Shinozaki R, Hasegawa Y, Kikuchi R, Senjo H, Yoneda K, Zhang Z, Harada S, Hayase E, Ara T, Ohigashi H, Iwakura Y, Nakamura K, Ayabe T, Teshima T. Reactive granulopoiesis depends on T-cell production of IL-17A and neutropenia-associated alteration of gut microbiota. <strong><em>Proc Natl Acad Sci U.S.A.<\/em><\/strong> 2022. 119(48):e2211230119. doi: 10.1073\/pnas.2211230119<\/li>\n<li>Funane T, Yokoi Y, Kiguchi M, Shinozaki R, Ayabe T, Atsumori H, Nishimura A, Nakamura K, Kandori A. Hemodynamic response to intestinal pH stimulation measured with spectroscopic video imaging. <strong><em>Biomed Phys Eng Express<\/em><\/strong> 2022. 9(1). doi: 10.1088\/2057-1976\/aca20a<\/li>\n<li><span lang=\"EN-GB\">Kamioka M, Goto Y, Nakamura K, Yokoi Y, Sugimoto R, Ohira S, Kurashima Y, Umemoto S, Sato S, Kunisawa J, Takahashi Y, Domino SE, Renauld JC, Nakae S, Iwakura Y, Ernst PB, Ayabe T, Kiyono H. Intestinal commensal microbiota and cytokines regulate Fut2<sup>+<\/sup> Paneth cells for gut defense.<b><i> <\/i><\/b><\/span><b><i><\/i><\/b><b><i><\/i><\/b><span lang=\"EN-GB\"><b><i>Proc Natl Acad Sci U.S.A.<\/i><\/b> 2022. doi: 10.1073\/pnas.2115230119.<\/span><\/li>\n<li>\n<div><span lang=\"EN-US\">Baba H, Watanabe Y, Miura K, Okada K, Kondo M, Ozaki K, Hasebe A, Ayabe T, Nakamura K, Aizawa T, Nakaoka S, Ogasawara K, Suzuki T, Saito H, Kimura T, Tamakoshi A, Yamazaki Y. Oral frailty and carriage of oral Candida in community-dwelling older adults (Checkup to discover Health with Energy for senior Residents in Iwamizawa; CHEER Iwamizawa) <b><i>Gerodontology<\/i><\/b> 2022. doi: 10.1111\/ger.12621<\/span><\/div>\n<\/li>\n<li><span lang=\"EN-GB\"><span lang=\"EN-GB\">Kotake K, Kumazawa T, Nakamura K, Shimuzu Y, Ayabe T, Adachi T. Ingestion of miso regulates immunological robustness in mice. <b><i>PLoS One<\/i><\/b>\u00a02022.\u00a0<\/span><\/span><span style=\"font-size: revert; color: initial;\">17(1): e0261680. doi: 10.1371\/journal.pone.0261680<\/span><\/li>\n<li><span lang=\"EN-GB\"><span lang=\"EN-GB\">Sato Y, Wang Y, Song Y, Geng W, Yan S, Nakamura K, Kikukawa T, Demura M, Ayabe T, Aizawa T. Potent bactericidal activity of reduced cryptdin-4 derived from its hydrophobicity and mediated by bacterial membrane disruption. <b><i>Amino Acids<\/i><\/b> 2022.\u00a0<\/span><\/span><span style=\"color: initial;\">doi: 10.1007\/s00726-021-03115-3<\/span><\/li>\n<li>\n<div><span lang=\"EN-US\">Shimizu Y, Nakamura K, Kikuchi M, Ukawa S, Nakamura K, Okada E, Imae A, Nakagawa T, Yamamura R, Tamakoshi A, Ayabe T. Lower human defensin 5 in elderly people compared to middle-aged is associated with differences in the intestinal microbiota composition: the DOSANCO Health Study. <em><b>GeroScience<\/b><\/em> 2021. doi: 10.1007\/s11357-021-00398-y.<\/span><\/div>\n<\/li>\n<li>\n<div><span lang=\"EN-GB\">Suzuki K, Nakamura K, Shimizu Y, Yokoi Y, Hagiwara M, Ohira S, Wang Y, Song Y, Aizawa T, Ayabe T. Decrease of <\/span><span lang=\"EN-US\">\u03b1<\/span><span lang=\"EN-GB\">-defensin impairs intestinal metabolite homeostasis via dysbiosis in mouse chronic social defeat stress model. <em><b>Sci Rep<\/b><\/em> 2021. 11: 9915. doi: 10.1038\/s41598-021-89308-y.<\/span><\/div>\n<\/li>\n<li>Yokoi Y, Adachi T, Sugimoto R, Kikuchi M, Ayabe T, Nakamura K. Simultaneous real-time analysis of Paneth cell and intestinal stem cell response to interferon-\u03b3 by a novel stem cell niche tracking method. <em><strong>Biochem Biophys Res Commun<\/strong><\/em> 2021. 545: 14-19. doi.org\/10.1016\/j.bbrc.2021.01.050.<\/li>\n<li>Nakamura K, Yokoi Y, Fukaya R, Ohira S, Shinozaki R, Nishida T, Kikuchi M, Ayabe T. Expression and localization of Paneth cells and their \u03b1-defensins in the small intestine of adult mouse. <em><strong>Front Immunol<\/strong><\/em> 2020. 11: 570296. doi: 10.3389\/fimmu.2020.570296.<\/li>\n<li>Hanyu H, Yokoi Y, Nakamura K, Ayabe T, Tanaka K, Uno K, Miyajima K, Saito Y, Iwatsuki K, Shimizu M, Tadaishi M, Kobayashi-Hattori K. Mycotoxin deoxynivalenol has different impacts on intestinal barrier and stem cells by its route of exposure. <em><strong>Toxins<\/strong><\/em> 2020. 12: 610. doi: 10.3390\/toxins12100610.<\/li>\n<li>Shimizu Y, Nakamura K, Yoshii A, Yokoi Y, Kikuchi M, Shinozaki R, Nakamura S, Ohira S, Sugimoto R, Ayabe T. Paneth cell \u03b1-defensin misfolding correlates with dysbiosis and ileitis in Crohn\u2019s disease model mice. <em><strong>Life Science Alliance<\/strong><\/em> 2020. doi: 10.26508\/lsa.201900592.<\/li>\n<li>Komatsu Y, Shimizu Y, Yamano M, Kikuchi M, Nakamura K, Ayabe T, Aizawa T. Disease progression-associated alterations in fecal metabololies in SAMP1\/YitFc mice, a Crohn\u2019s disease model. <em><strong>Metabolomics<\/strong><\/em> 2020. 16: 48. doi: 10.1007\/s11306-020-01671-5.<\/li>\n<li>Hirabayashi Y, Nakamura K, Sonehara T, Suzuki D, Hanzawa S, Shimizu Y, Aizawa T, Nakamura K, Tamakoshi A, Ayabe T. Analysis of serotonin in human feces using solid phase extraction and column-switching LC-MS\/MS. <em><strong>Mass Spectrometry<\/strong><\/em> 2020. doi: 10.5702\/massspectrometry.A0081.<\/li>\n<li>Takakuwa A, Nakamura K, Kikuchi M, Sugimoto R, Ohira S, Yokoi Y, Ayabe T. Butyric acid and leucine induce \u03b1-defensin secretion from small intestinal Paneth cells. <em><strong>Nutrients<\/strong><\/em> 2019, 11(11), 2817; doi: 10.3390\/nu11112817.<\/li>\n<li>Yamamura R, Nakamura K, Kitada N, Aizawa T, Schimizu Y, Nakamura K, Ayabe T, Kimura T, Tamakoshi A. Associations of gut microbiota, dietary intake, and serum short-chain fatty acids with fecal short-chain fatty acids. <em><strong>Biosci Microbiota Food Health <\/strong><\/em>2019, doi.org\/10.12938\/bmfh.19-010.<\/li>\n<li>Shimizu Y, Sakuragi N, Nakamura K, Taira T, Ayabe T, Fukui A. A simple culture method for liver and intestinal tissue-resident macrophages from neonatal mice. <strong>In Vitro Cell Dev Biol Anim <\/strong>doi.org\/10.1007\/s11626-019-00359-y<\/li>\n<li><span lang=\"EN-GB\">Yokoi Y, Nakamura K, Yoneda T, Kikuchi M, Sugimoto R, Shimizu Y, Ayabe T. Paneth cell granule dynamics on secretory responses to bacterial stimuli in enteroids. <b><em>Sci Rep<\/em>\u00a0<\/b>doi.org\/10.1038\/s41598-019-39610-7.<\/span><\/li>\n<li>Pillai MR, Mihi B, Ishiwata K, Nakamura K, Sakuragi N, Finkelstein DB, McGargill MA, Nakayama T, Ayabe T, Coleman ML, Bix M. Myc-induced nuclear antigen constrains a latent intestinal epithelial cell-intrinsic anthelmintic pathway. <b><i>PLoS One<\/i><\/b><strong>\u00a0<\/strong><span lang=\"EN\">doi: 10.1038\/s41598-019-39610-7<\/span><span lang=\"EN\">.<\/span><\/li>\n<li>Eriguchi Y, Nakamura K, Yokoi Y, Takahashi S, Hashimoto D, Teshima T, Ayabe T, Selsted ME, Ouellette AJ. Essential role of interferon-gamma in T cell-associated intestinal inflammation. <strong><em>JCI Insight<\/em>\u00a0<\/strong>2018. 3(18): e121886. doi.org\/10.1172\/jci.insight.121886.<\/li>\n<li>Yaguchi K, Yamamoto T, Shimada M, Sugimoto R, Nakamura K, Ayabe T, Uehara R. Ploidy-dependent change in cyclin D2 expression and sensitization to cdk4\/6 inhibition in human somatic haploid cells. <strong><em>Biochem Biophys Res Commun<\/em>\u00a0<\/strong>2018. doi.org\/10.1016\/j.bbrc.2018.08.160.<\/li>\n<li><span lang=\"EN-GB\">Cobo ER, Holani R, Moreau F, Nakamura K, Ayabe T, Mastroiannid JR, Ouellette AJ, Chadee K. Entamoeba histolytica alters ileal Paneth cell functions in intact and Muc2 mucin deficiency. <em><b>Infect Immun\u00a0<\/b><\/em><\/span><span lang=\"EN-US\">2018. doi: 10.1128\/IAI.00208-18.<\/span><\/li>\n<li>Hayase E, Hashimoto D, Nakamura K, Noizat C, Ogasawara R, Takahashi S, Ohigashi H, Yokoi Y, Sugimoto R, Matsuoka S, Ara T, Yokoyama E, Yamakawa T, Ebata K, Kondo T, Hiramine R, Aizawa T, Ogura Y, Hayashi T, Mori H, Kurokawa K, Tomizuka K, Ayabe T, Teshima T. R-Spondin1 expands Paneth cells and prevents dysbiosis induced by graft-versus-host disease. <em><strong>J Exp Med<\/strong><\/em> doi: 10.1084\/jem.20170418.<\/li>\n<li>Nohara S, Kato K, Fujiwara D, Sakuragi N, Yanagihara K, Iwanuma Y, Kajiyama Y. Aminopeptidase N (APN\/CD13) as a target molecule for scirrhous gastric cancer. <em><strong>Clin Res Hepatol Gastroenterol<\/strong><\/em> 40: 494-503, 2016.<\/li>\n<li>Nakamura K, Sakuragi N, Takakuwa A, Ayabe T. Paneth cell \u03b1-defensins and enteric microbiota in health and disease. <em><strong>Biosci Microbiota Food Health<\/strong><\/em> 35: 57-67, 2016.<\/li>\n<li>Nohara S, Kato K, Fujiwara D, Sakuragi N, Yanagihara K, Iwanuma Y, Kajiyama Y. Aminopeptidase N (APN\/CD13) as a target molecule for scirrhous gastric cancer. <em><strong>Clin Res Hepatol Gastroenterol<\/strong><\/em> 40: 494-503, 2016.<\/li>\n<li>Nukuda A, Sasaki C, Ishihara S, Mizutani T, Nakamura K, Ayabe T, Kawabata K, Haga H. Stiff substrates increase YAP-signaling-mediated matrix metalloproteinase-7 expression. <em><strong>Oncogenesis<\/strong><\/em> 4: e165, 2015.<\/li>\n<li>Eriguchi Y, Nakamura K, Hashimoto D, Shimoda S, Shimono N, Akashi K, Ayabe T, Teshima T. Decreased Secretion of Paneth cell \u03b1-defensin in Graft-versus-host disease. <em><strong>Transpl Infect Dis<\/strong><\/em> 17: 702-706, 2015.<\/li>\n<li>Tomisawa S, Sato Y, Kamiya M, Kumaki Y, Kikukawa T, Kawano K, Demura M, Nakamura K, Ayabe T, Aizawa T. Efficient production of a correctly folded mouse \u03b1-defensin, cryptdin-4, by refolding during inclusion body solubilization. <em><strong>Protein Expr Purif<\/strong><\/em> 112: 21-28, 2015.<\/li>\n<li>Taira R, Yamaguchi S, Shimizu K, Nakamura K, Ayabe T, Taira T. Bacterial cell wall components regulate adipokine secretion from visceral adipocytes. <em><strong>J Clin Biochem Nutr<\/strong><\/em> 56: 149-154, 2015.<\/li>\n<li>Ikeda M, Yamaguchi M, Kato K, Nakamura K, Shiina S, Ichikawa-Ando T, Misaka H, Myojo K, Nakamura K, Sugimoto Y, Hamada H. Pr1E11, a novel anti-TROP-2 antibody isolated by adenovirus-based antibody screening, recognizes a unique epitope. <em><strong>Biochem Biophys Res Commun<\/strong><\/em> 458: 877-882, 2015.<\/li>\n<li>Yamaguchi M, Nishii Y, Nakamura K, Aoki H, Hirai S, Uchida H, Sakuma Y, Hamada H. Development of a sensitive screening method for selecting monoclonal antibodies to be internalized by cells. <em><strong>Biochem Biophys Res Commun<\/strong><\/em> 454: 600-603, 2014.<\/li>\n<li>Nakamura K, Sakuragi N, Ayabe T. A monoclonal antibody-based sandwich enzyme-linked immunosorbent assay for detection of secreted \u03b1-defensin. <em><strong>Anal Biochem<\/strong><\/em> 443: 124-131, 2013.<\/li>\n<li>Eriguchi Y, Uryu H, Nakamura K, Shimoji S, Takashima S, Iwasaki H, Miyamoto T, Shimono N, Hashimoto D, Akashi K, Ayabe T, Teshima T. Reciprocal expression of enteric antimicrobial proteins in intestinal graft-versus-host disease. <em><strong>Biol Blood Marrow Transplant<\/strong><\/em> 19: 1525-1529, 2013.<\/li>\n<li>Takemoto K, Matsuda T, Sakai N, Fu D, Noda M, Uchiyama S, Kotera I, Arai Y, Horiuchi M, Fukui K, Ayabe T, Inagaki F, Suzuki H, Nagai T. SuperNova, a monomeric photosensitizing fluorescent protein for chromophore-assisted light inactivation. <em><strong>Sci Rep<\/strong><\/em> 3: 026291-026297, 2013.<\/li>\n<li>Tanaka M, Kuribayashi K, Kogawa K, Nakamura K, Watanabe N. Intracellular superoxide dismutase activity defines invasiveness of the murine T-lymphoma cell line L5187Y-ML25 in vitro and in vivo. <em><strong>Leuk Res<\/strong><\/em> 37: 89-92, 2013.<\/li>\n<li>Eriguchi Y, Takashima S, Oka H, Shimoji S, Nakamura K, Uryu H, Shimoda S, Iwasaki H, Shimono N, Ayabe T, Akashi K, Teshima T. Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of \u03b1 -defensins. <em><strong>Blood<\/strong><\/em> 120: 223-231, 2012.<\/li>\n<li>Ito T, Tanabe H, Ayabe T, Ishikawa C, Inaba Y, Maemoto A, Kono T, Ashida T, Fujiya M, Kohgo Y. Paneth cells regulate both chemotaxis of immature dendritic cells and cytokine production from epithelial cells. <em><strong>Tohoku J Exp Med<\/strong><\/em> 227: 39-48, 2012.<\/li>\n<li>Konno Y, Ashida T, Inaba Y, ItoT, Tanabe H, Maemoto A, Ayabe T, Mizukami Y, Fujiya M, Kohgo Y. Isoleucine, an Essential Amino Acid, Induces the Expression of Human \u03b2 Defensin 2 through the Activation of the G-Protein Coupled Receptor-ERK Pathway in the Intestinal Epithelia. <em><strong>Food Nutrition Sciences<\/strong><\/em> 3: 548-555, 2012.<\/li>\n<li>Sato Y, Tomisawa S, Aizawa T, Sakai N, Kamiya M, Kikukawa T, Kumaki Y, Demura M, Ayabe T, Kawano K. Conststruction of a novel expression system for cryptdin-4 by using inclusion body formation. <em><strong>Peptide Science 2011<\/strong><\/em> 393-394, 2012.<\/li>\n<li>Nakamura K, Ayabe T. Paneth cells and stem cells in the intestinal stem cell niche and their association with inflammatory bowel disease.<br \/>\n<em><strong>Inflammation Regeneration<\/strong><\/em> 32: 53-60, 2012.<\/li>\n<li>Masuda K, Nakamura K, Yoshioka S, Fukaya R, Sakai N, Ayabe T. Regulation of microbiota by antimicrobial peptides in the gut.<br \/>\n<em><strong>Adv Otorhinolaryngol<\/strong><\/em> 72: 97-99, 2011.<\/li>\n<li>Masuda K, Sakai N, Nakamura K, Yoshioka S, Ayabe T. Bactericidal activity of mouse \u03b1-defensin, cryptdin-4 predominantly affects non-commensal bacteria.<br \/>\n<em><strong>J Innate Immun<\/strong><\/em> 3: 315-326, 2011.<\/li>\n<li>Son SH, Abe Y, Yuasa M, Yamagishi Y, Sakai N, Ayabe T, Yamada K. A systematic analysis of aromatic heterocyclic rings in solvatochromic fluorophores.<br \/>\n<em><strong>Chem Lett<\/strong><\/em> 40(4): 378-380, 2011.<\/li>\n<li>Kawaguchi A, Suzuki T, Sakai N, Kimura T, Ayabe T, Hasegawa H, Sawa H. Functional analysis of an \u03b1-helical antimicrobial peptide derived from a novel mouse defensin-like gene.<br \/>\n<em><strong>Biochm Biophys Res Commun<\/strong><\/em> 398: 778-784, 2010.<\/li>\n<li>Inaba Y, Ashida T, Ito T, Ishikawa C, Tanabe H, Maemoto A, Watari J, Ayabe T, Mizukami Y, Fujiya M, Kohgo Y. Expression of the antimicrobial peptide \u03b1-defensin\/cryptdins in intestinal crypts decreases at the initial phase of intestinal inflammation in a model of inflammatory bowel disease, IL-10-deficient mice.<br \/>\n<em><strong>Inflamm Bowel Dis<\/strong><\/em> 16: 1488-1495, 2010.<\/li>\n<li>Ishikawa C, Tanabe H, Maemoto A, Ito T, Watari J, Kono T, Fujiya M, Ashida T, Ayabe T, Kohgo Y. Precursor processing of human defensin-5 is essential to the multiple functions in vitro and in vivo.<br \/>\n<em><strong>J Innate Immun<\/strong><\/em> 2: 66-76, 2010.<\/li>\n<li>Tamura S, Amano S, Kono T, Kondoh J, Yamaguchi K, Kobayashi S, Ayabe T, Moriyama T. Molecular characteristics and physiological functions of major royal jelly protein 1 oligomer.<br \/>\n<em><strong>Proteomics<\/strong><\/em> 9: 5534-5543, 2009.<\/li>\n<li>Tanabe H, Sato T, Watari J, Maemoto A, Fujiya M, Kono T, Ashida T, Ayabe T, Kohgo Y. Functional role of metaplastic Paneth cell defensins in Helicobacter pylori-infected stomach.<br \/>\n<em><strong>Helicobacter<\/strong><\/em> 13: 370-379, 2008.<\/li>\n<li>Sakai N, Ayabe T. Antimicrobial peptides in the gut innate immunity.<br \/>\n<em><strong>Int J Probiotics Prebiotics<\/strong><\/em> 3: 123-126, 2008.<\/li>\n<li>Tanabe H, Ayabe T, Maemoto A, Ishikawa C, Inaba Y, Sato R, Moriichi K, Okamoto K, Watari J, Kono T, Ashida T, Kohgo Y. Denatured human \u03b1-defensin attenuates the bactericidal activity and the stability against enzymatic digestion.<br \/>\n<em><strong>Biochm Biophys Res Commun<\/strong><\/em> 358: 349-355, 2007.<\/li>\n<li>Tanabe H, Ayabe T, Bainbridge B, Guina T, Ernst RK, Darveau RP, Miller SI, Ouellette AJ. Mouse Paneth cell responses to cell surface glycolipids of virulent and attenuated pathogenic bacteria.<br \/>\n<em><strong>Infect Immun<\/strong><\/em> 73: 2312-2320, 2005.<\/li>\n<li>Ayabe T, Ashida T, Kohgo Y, Kono T. The role of Paneth cells and their antimicrobial peptides in innate host defense.<br \/>\n<em><strong>Trends Microbiol<\/strong><\/em> 12: 394-398, 2004.<\/li>\n<li>Kohgo Y, Ashida T, Maemoto A, Ayabe T. Leukocytapheresis for treatment of IBD.<br \/>\n<em><strong>J Gastroenterol<\/strong><\/em> [Suppl XV]: 31-34, 2003.<\/li>\n<li>Ayabe T, Satchell DP, Pesendorfer P, Tanabe H, Wilson CL, Hagen SJ, Ouellette AJ. Activation of Paneth cell \u03b1-defensins in mouse small intestine.<br \/>\n<em><strong>J Biol Chem<\/strong><\/em> 277: 5219-5228, 2002.<\/li>\n<li>Ayabe T, Wulff H, Darmoul D, Cahalan MD, Chandy KG, Ouellette AJ. Modulation of mouse Paneth cell \u03b1-defensin secretion by mIKCa1, a Ca<span class=\"text-sp\">2+<\/span>-activated, intermediate conductance Potassium channel.<br \/>\n<em><strong>J Biol Chem<\/strong><\/em> 277: 3793-3800, 2002.<\/li>\n<li>Ayabe T, Satchell DP, Wilson CW, Parks WC, Selsted ME, Ouellette AJ. Secretion of microbicidal \u03b1-defensins by intestinal Paneth cells in response to bacteria.<br \/>\n<em><strong>Nature Immunol<\/strong><\/em> 1: 113-118, 2000.<\/li>\n<li>Honda M, Orii F, Ayabe T, Imai S, Ashida T, Obara T, Kohgo Y. Expression of glucocorticoid receptor \u03b2 in lymphocytes of patients with glucocorticord-resistant ulcerative colitis.<br \/>\n<em><strong>Gastroenterology<\/strong><\/em> 118: 859-866, 2000.<\/li>\n<li>Wilson CL, Ouellette AJ, Satchell DP, Ayabe T, Lopez-Boado YS, Stratman JL, Hultgren SJ, Matrisian LM, Parks WC. Regulation of intestinal \u03b1-defensin activation by the metalloproteinase matrilysin in innate host defense.<br \/>\n<em><strong>Science<\/strong><\/em> 286: 113-117, 1999.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u8ad6\u6587(\u4e00\u90e8) Shimizu Y, Yokoi Y, Ohira S, Izumi H, Kawakami S, Ihara M, Tabata F, Takeda Y, Kimura T, Nakamura K, Ta [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":7,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-17","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/altair.sci.hokudai.ac.jp\/infsig\/wp-json\/wp\/v2\/pages\/17","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/altair.sci.hokudai.ac.jp\/infsig\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/altair.sci.hokudai.ac.jp\/infsig\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/altair.sci.hokudai.ac.jp\/infsig\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/altair.sci.hokudai.ac.jp\/infsig\/wp-json\/wp\/v2\/comments?post=17"}],"version-history":[{"count":29,"href":"https:\/\/altair.sci.hokudai.ac.jp\/infsig\/wp-json\/wp\/v2\/pages\/17\/revisions"}],"predecessor-version":[{"id":835,"href":"https:\/\/altair.sci.hokudai.ac.jp\/infsig\/wp-json\/wp\/v2\/pages\/17\/revisions\/835"}],"wp:attachment":[{"href":"https:\/\/altair.sci.hokudai.ac.jp\/infsig\/wp-json\/wp\/v2\/media?parent=17"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}