Macrophage Migration Inhibitor Factor
Macrophage Migration Inhibitory Factor (MIF)
![[Macrophage Migration Inhibitory Factor]](hmif.gif)
Macrophage Migration Inhibitory Factor (MIF) was originally identified as a cytokine, derived from T-lymphocytes to prevent the mobilization og guinea-pig macrophages in vitro. Further investigation revealed that MIF is secreted from the pituitary and macrophages by lipopolysaccharide (LPS) stimulation, and counter-regulates the immunosuppresive effects of glucocorticoid to act as a critical component of the immunity system. Many other properties of MIF, besides its property as a immunoregulatory protein have also found. MIF exists not only in immune cells, but also in other cell types such as chicken differentiating cells of the eye lens, mouse 3T3 fibroblastic cells and rat liver cells.
References
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Crystallization of Rat Liver Macrophage Migration Inhibitory Factor (MIF) for MAD Analysis
Hiroshi Sugimoto, Mamoru Suzuki, Atsushi Nakagawa, Isao Tanaka and
Mami Fujinaga, Jun Nishihira
J. Struct. Biol., 115, 331-334 (1995)
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Crystal structure of the macrophage migration inhibitory factor from rat liver
Mamoru Suzuki, Hiroshi Sugimoto, Atsushi Nakagawa, Isao Tanaka, Jun Nishihira and Masaharu Sakai
Nature Struct. Biol, 3, 259-266 (1996)
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Crystal structure of macrophage migration inhibitory factor from human lymphocyte at 2.1A resolution
Hiroshi Sugimoto, Mamoru Suzuki, Atsushi Nakagawa, Isao Tanaka and
Jun Nishihira
FEBS Letters, 389, 145-148 (1996)
